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首页> 外文期刊>Annals of Biomedical Engineering: The Journal of the Biomedical Engineering Society >The Effect of Head Rotation on the Geometry and Hemodynamics of Healthy Vertebral Arteries
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The Effect of Head Rotation on the Geometry and Hemodynamics of Healthy Vertebral Arteries

机译：头部旋转对健康椎动脉的几何形状和血流动力学的影响

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摘要

The geometric and hemodynamic characteristics of the left and right vertebral arteries (LVA, RVA) of six healthy volunteers were investigated for the supine (S) and the prone position (P) a common sleeping posture with head rotation. MRI images were used to reconstruct the subject specific three-dimensional solid models of the LVA and RVA from the level of the carotid bifurcation to the vertebrobasilar junction (VJ). Geometric parameters such as cross sectional area ratio, curvature, tortuosity and branch angle were estimated. MR-PCA was used to obtain the blood flow waveforms for the two positions and computational fluid dynamics (CFD) were used to assess the flow field in terms of wall shear stress (WSS) relative residence times (RRT) and localized normalized helicity (LNH). Significant geometric changes but moderate flow changes were observed for both vertebral arteries with head rotation. The CFD results at the VJ show that head rotation causes changes in the WSS distribution, RRT and LNH. Further studies are warranted to assess the clinical significance of the results in terms of atherosclerosis development at the VJ and how the observed geometric changes may affect blood flow to the brain in healthy subjects and vertebral artery stenosis patients, and in terms of increased rapture susceptibility in vertebrobasilar aneurysm patients.
机译：研究了六名健康志愿者的左，右椎动脉（LVA，RVA）的几何和血液动力学特征，以仰卧位（S）和俯卧位（P）作为头部旋转的常见睡眠姿势。 MRI图像用于重建从颈动脉分叉到椎基底连接（VJ）的LVA和RVA的特定三维立体模型。估算了几何参数，例如横截面积比，曲率，曲折度和分支角。 MR-PCA用于获得两个位置的血流波形，计算流体动力学（CFD）用于根据壁切应力（WSS）相对停留时间（RRT）和局部归一化螺旋度（LNH）评估流场）。头部旋转时，两个椎动脉均观察到明显的几何变化，但流量适度变化。 VJ处的CFD结果表明，磁头旋转导致WSS分布，RRT和LNH发生变化。有必要进行进一步的研究，以评估结果的临床意义，包括VJ的动脉粥样硬化发展，观察到的几何变化如何影响健康受试者和椎动脉狭窄患者的大脑血流，以及是否增加易怒性。椎基底动脉瘤患者。

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