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首页> 外文期刊>The Canadian journal of hospital pharmacy. >Osmolality of Medications Administered in the Neonatal Intensive Care Unit
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Osmolality of Medications Administered in the Neonatal Intensive Care Unit

机译：在新生儿重症监护病房中施用的药物渗透压

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摘要

The most recent recommendations regarding enteral feeding solutions for newborns state that they should have a maximum osmolality of 450 mOsm/kg (400 mOsm/L) and that the use of hyperosmolar feeding solutions may be a factor in the development of necrotizing enterocolitis. These recommendations are based on historical consensus, and there is little other evidence to guide this practice. For preterm newborns at risk of necrotizing enterocolitis, or infants at risk of osmotic diarrhea because of gastrointestinal abnormalities, enteral medications are often diluted in small amounts of breast milk or formula (usual osmolality about 300 mOsm/kg), both for ease of administration and to reduce the osmolar challenge of the medications. Unfortunately, for many compounded and commercially available oral liquid medications, published osmolality values are not available to clinicians to aid in assessing the osmolar load and the risks associated with enteral administration.
机译：关于新生儿肠道喂养溶液的最新建议指出，新生儿的最大渗透压应为450 mOsm/kg（400 mOsm/L），使用高渗喂养溶液可能是坏死性小肠结肠炎的一个因素。这些建议基于历史共识，几乎没有其他证据来指导这一实践。对于有坏死性小肠结肠炎风险的早产儿，或因胃肠道异常而有渗透性腹泻风险的婴儿，肠内药物通常在少量母乳或配方奶粉中稀释（通常渗透压约为300 mOsm/kg），以便于服用，并减少药物的渗透压挑战。不幸的是，对于许多复方和市售口服液药物，临床医生无法获得公布的渗透压值，以帮助评估渗透压负荷和与肠道给药相关的风险。

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