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首页> 外文期刊>The Canadian Journal of Neurological Sciences: le Journal Canadien des Sciences Neurologiques >Neurological Manifestations in COVID-19 Infection: A Systematic Review and Meta-Analysis
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Neurological Manifestations in COVID-19 Infection: A Systematic Review and Meta-Analysis

机译：Covid-19感染中的神经系统表现：系统审查和荟萃分析

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Background: Growing evidence showed that coronavirus disease 2019 (COVID-19) infection may present with neurological manifestations. This review aimed to determine the neurological manifestations and complications in COVID-19. Methods: We conducted a systematic review and meta-analysis that included cohort and case series/reports involving a population of patients confirmed with COVID-19 infection and their neurologic manifestations. We searched the following electronic databases until April 18, 2020: PubMed, Embase, Scopus, and World Health Organization database (PROSPERO registration number: CRD42020180658). Results: From 403 articles identified, 49 studies involving a total of 6,335 confirmed COVID-19 cases were included. The random-effects modeling analysis for each neurological symptom showed the following proportional point estimates with 95% confidence intervals: "headache" (0.12; 0.10-0.14; I~2 = 77%), "dizziness" (0.08; 0.05-0.12; I~2 = 82%), "headache and dizziness" (0.09; 0.06-0.13; I~2 = 0%), "nausea" (0.07; 0.04-0.11; I~2= 79%), "vomiting" (0.05; 0.03-0.08; I~2 = 74%), "nausea and vomiting" (0.06; 0.03-0.11; I2 = 83%), "confusion" (0.05; 0.02-0.14; I~2 = 86%), and "myalgia" (0.21; 0.18-0.25; I~2 = 85%). The most common neurological complication associated with COVID-19 infection was vascular disorders (n = 23); other associated conditions were encephalopathy (n = 3), encephalitis (n = 1), oculomotor nerve palsy (n = 1), isolated sudden-onset anosmia (n = 1), Guillain-Barré syndrome (n = 1), and Miller-Fisher syndrome (n = 2). Most patients with neurological complications survived (n = 14); a considerable number of patients died (n = 7); and the rest had unclear outcomes (n = 12). Conclusion: This review revealed that neurologic involvement may manifest in CO VID-19 infection. What has initially been thought of as a primarily respiratory illness has evolved into a wide-ranging multi-organ disease.
机译：背景：越来越多的证据表明，2019年冠状病毒病（COVID-19）感染可能表现为神经系统症状。本文旨在探讨2019冠状病毒疾病的神经系统表现和并发症。方法：我们进行2019冠状病毒疾病的患者和神经系统症状的队列和病例系列/报告的系统回顾和荟萃分析。截至2020年4月18日，我们搜索了以下电子数据库：PubMed、Embase、Scopus和世界卫生组织数据库（PROSPERO注册号：CRD420180658）。结果：从2019冠状病毒疾病中检出403篇，共纳入49篇研究，共6335篇。每种神经症状的随机效应建模分析显示了以下95%置信区间的比例点估计值：“头痛”（0.12；0.10-0.14；I~2=77%），“头晕”（0.08；0.05-0.12；I~2=82%），“头痛和头晕”（0.09；0.06-0.13；I~2=0%），“恶心”（0.07；0.04-0.11；I~2=79%），“呕吐”（0.05；0.03-0.08；I~2=74%），“恶心呕吐”（0.06；0.03-0.11；I2=83%），“困惑”（0.05；0.02-0.14；I2=86%）和“肌痛”（0.21；0.18-0.25；I2=85%）。2019冠状病毒疾病最常见的神经并发症为血管障碍（n＝23）；其他相关疾病包括脑病（n=3）、脑炎（n=1）、动眼神经麻痹（n=1）、孤立性突发性嗅觉缺失（n=1）、格林-巴利综合征（n=1）和米勒-费舍尔综合征（n=2）。大多数神经系统并发症患者存活（n=14）；相当数量的患者死亡（n=7）；其余的结果不清楚（n=12）。结论：这篇综述显示，CO-VID-19感染可能表现为神经系统受累。最初被认为主要是呼吸系统疾病的疾病已经演变成范围广泛的多器官疾病。

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