Nutritional control of antibiotic production by Streptomyces platensis MA7327: importance of L-aspartic acid

Falzone Maria; Crespo Emmanuel; Jones Klarissa; Khan Gulaba; Korn Victoria L.; Patel Amreen; Patel Mira; Patel Krishnaben; Perkins Carrie; Siddiqui Sana; Stenger Drew; Yu Eileen; Gelber Michael; Scheffler Robert; Nayda Vasyl; Ravin Ariela; Komal Ronica; Rudolf Jeffrey D.; Shen Ben; Gullo Vincent; Demain Arnold L.

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Nutritional control of antibiotic production by Streptomyces platensis MA7327: importance of L-aspartic acid

机译：用链霉菌的抗生素生产营养控制Platensis MA7327：L-天冬氨酸的重要性

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Streptomyces platensis MA7327 is a bacterium producing interesting antibiotics, which act by the novel mechanism of inhibiting fatty acid biosynthesis. The antibiotics produced by this actinomycete are platensimycin and platencin plus some minor related antibiotics. Platensimycin and platencin have activity against antibiotic-resistant bacteria such as methicillin-resistant Staphylococcus aureus and vancomycin-resistant Enterococcus; they also lack toxicity in animal models. Platensimycin also has activity against diabetes in a mouse model. We have been interested in studying the effects of primary metabolites on production of these antibiotics in our chemically defined production medium. In the present work, we tested 32 primary metabolites for their effect. They included 20 amino acids, 7 vitamins and 5 nucleic acid derivatives. Of these, only L-aspartic acid showed stimulation of antibiotic production. We conclude that the stimulatory effect of aspartic acid is due to its role as a precursor involved in the biosynthesis of aspartate-4-semialdehyde, which is the starting point for the biosynthesis of the 3-amino-2,4-dihydroxy benzoic acid portion of the platensimycin molecule.

机译：钝顶链霉菌MA7327是一种产生有趣抗生素的细菌，其通过抑制脂肪酸生物合成的新机制发挥作用。由这种放线菌产生的抗生素是铂霉素和铂霉素加上一些次要的相关抗生素。铂霉素和铂霉素对耐甲氧西林金黄色葡萄球菌和耐万古霉素肠球菌等抗生素耐药细菌具有活性；它们在动物模型中也缺乏毒性。在小鼠模型中，钝顶霉素也具有抗糖尿病的活性。我们一直有兴趣在我们的化学定义的生产介质中研究初级代谢物对这些抗生素生产的影响。在目前的工作中，我们测试了32种初级代谢物的效果。它们包括20种氨基酸、7种维生素和5种核酸衍生物。其中，只有L-天冬氨酸能刺激抗生素的产生。我们得出结论，天冬氨酸的刺激作用是由于其作为参与天冬氨酸-4-半醛生物合成的前体的作用，天冬氨酸-4-半醛是铂霉素分子中3-氨基-2,4-二羟基苯甲酸部分生物合成的起点。

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《The Journal of Antibiotics: An International Journal》 |2017年第7期|共4页
作者
Falzone Maria; Crespo Emmanuel; Jones Klarissa; Khan Gulaba; Korn Victoria L.; Patel Amreen; Patel Mira; Patel Krishnaben; Perkins Carrie; Siddiqui Sana; Stenger Drew; Yu Eileen; Gelber Michael; Scheffler Robert; Nayda Vasyl; Ravin Ariela; Komal Ronica; Rudolf Jeffrey D.; Shen Ben; Gullo Vincent; Demain Arnold L.;
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Drew Univ Charles A Dana Res Inst RISE HS-330 Madison NJ 07940 USA;

Drew Univ Charles A Dana Res Inst RISE HS-330 Madison NJ 07940 USA;

Drew Univ Charles A Dana Res Inst RISE HS-330 Madison NJ 07940 USA;

Drew Univ Charles A Dana Res Inst RISE HS-330 Madison NJ 07940 USA;

Drew Univ Charles A Dana Res Inst RISE HS-330 Madison NJ 07940 USA;

Drew Univ Charles A Dana Res Inst RISE HS-330 Madison NJ 07940 USA;

Drew Univ Charles A Dana Res Inst RISE HS-330 Madison NJ 07940 USA;

Drew Univ Charles A Dana Res Inst RISE HS-330 Madison NJ 07940 USA;

Drew Univ Charles A Dana Res Inst RISE HS-330 Madison NJ 07940 USA;

Drew Univ Charles A Dana Res Inst RISE HS-330 Madison NJ 07940 USA;

Drew Univ Charles A Dana Res Inst RISE HS-330 Madison NJ 07940 USA;

Drew Univ Charles A Dana Res Inst RISE HS-330 Madison NJ 07940 USA;

Drew Univ Charles A Dana Res Inst RISE HS-330 Madison NJ 07940 USA;

Drew Univ Charles A Dana Res Inst RISE HS-330 Madison NJ 07940 USA;

Drew Univ Charles A Dana Res Inst RISE HS-330 Madison NJ 07940 USA;

Drew Univ Charles A Dana Res Inst RISE HS-330 Madison NJ 07940 USA;

Drew Univ Charles A Dana Res Inst RISE HS-330 Madison NJ 07940 USA;

Scripps Res Inst Dept Chem Jupiter FL USA;

Scripps Res Inst Dept Chem Jupiter FL USA;

Drew Univ Charles A Dana Res Inst RISE HS-330 Madison NJ 07940 USA;

Drew Univ Charles A Dana Res Inst RISE HS-330 Madison NJ 07940 USA;

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2. Amino acids and mammary gland development: nutritional implications for milk production and neonatal growth [J] . Reza Rezaei, Zhenlong WU, Yongqing Hou, 畜牧与生物技术杂志(英文版) . 2016,第004期
3. Effects of Nutritional Factors on the Growth and Heterotrophic Eicosapentaenoic Acid Production of Diatom Nitzschia laevis [J] . CAO Xiaohong, LI Songyao, WANG Chunling, 中国海洋大学学报（英文版） . 2008,第003期
4. Nutritional control of antibiotic production by Streptomyces platensis MA7327: importance of L-aspartic acid [J] . Falzone Maria, Crespo Emmanuel, Jones Klarissa, The Journal of Antibiotics: An International Journal . 2017,第7期

机译：用链霉菌的抗生素生产营养控制Platensis MA7327：L-天冬氨酸的重要性
5. Development of a chemically defined medium for the production of the antibiotic platensimycin by Streptomyces platensis [J] . Falzone M., Martens E., Tynan H., Applied Microbiology and Biotechnology . 2013,第21期

机译：化学定义培养基的开发，用于通过链霉菌生产抗生素板霉素
6. RESORMYCIN, A NOVEL HERBICIDAL AND ANTIFUNGAL ANTIBIOTIC PRODUCED BY A STRAIN OF STREPTOMYCES PLATENSIS - I - TAXONOMY, PRODUCTION, ISOLATION AND BIOLOGICAL PROPERTIES [J] . Igarashi M., Ikeda T., Kameda M., The Journal of Antibiotics: An International Journal . 1997,第12期

机译：RESORMYCIN，一株链霉菌感染产生的新型除草剂和抗真菌药-I-分类法，生产，分离和生物学特性
7. Nutritional limitation modelling for continuous control of lactic acid production by Lactobacillus casei [C] . Ben-Youssef C., Olmos-Dichara A. European Control Conference . 2001

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8. Platensimycin and Platencin Biosynthesis in Streptomyces platensis: Exploring Nature's Biological Machinery for the Discovery and Development of Useful Compounds. [D] . Peterson, Ryan Matthew. 2012

机译：铂链霉菌中的Platensimycin和Platencin生物合成：探索自然界发现有用化合物的生物机制。
9. Nutritional control of antibiotic production by Streptomyces platensis MA7327: importance of L-aspartic acid [O] . Maria Falzone, Emmanuel Crespo, Klarissa Jones, -1

机译：链霉菌MA7327对抗生素生产的营养控制：L-天冬氨酸的重要性
10. Nutritional control of antibiotic production by Streptomyces platensis MA7327: importance of l-aspartic acid [O] . Maria Falzone, Emmanuel Crespo, Klarissa Jones, 2017

机译：用链霉菌蛋白质抗生素生产营养控制Platensis MA7327：L-天冬氨酸的重要性
11. Enterotoxin B Production by Staphylococcus aureus under Controlled Fatty Acid Nutrition Induced by Cerulenin, [R] . altenbern,robert a. 1977

机译：金黄色葡萄球菌在Cerulenin诱导的可控脂肪酸营养下产生肠毒素B，

Nutritional control of antibiotic production by Streptomyces platensis MA7327: importance of L-aspartic acid

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