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首页> 外文期刊>The Journal of Antibiotics: An International Journal >Nutritional control of antibiotic production by Streptomyces platensis MA7327: importance of L-aspartic acid
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Nutritional control of antibiotic production by Streptomyces platensis MA7327: importance of L-aspartic acid

机译：用链霉菌的抗生素生产营养控制Platensis MA7327：L-天冬氨酸的重要性

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摘要

Streptomyces platensis MA7327 is a bacterium producing interesting antibiotics, which act by the novel mechanism of inhibiting fatty acid biosynthesis. The antibiotics produced by this actinomycete are platensimycin and platencin plus some minor related antibiotics. Platensimycin and platencin have activity against antibiotic-resistant bacteria such as methicillin-resistant Staphylococcus aureus and vancomycin-resistant Enterococcus; they also lack toxicity in animal models. Platensimycin also has activity against diabetes in a mouse model. We have been interested in studying the effects of primary metabolites on production of these antibiotics in our chemically defined production medium. In the present work, we tested 32 primary metabolites for their effect. They included 20 amino acids, 7 vitamins and 5 nucleic acid derivatives. Of these, only L-aspartic acid showed stimulation of antibiotic production. We conclude that the stimulatory effect of aspartic acid is due to its role as a precursor involved in the biosynthesis of aspartate-4-semialdehyde, which is the starting point for the biosynthesis of the 3-amino-2,4-dihydroxy benzoic acid portion of the platensimycin molecule.
机译：Streptomyces Platensis MA7327是一种产生有趣的抗生素的细菌，其通过抑制脂肪酸生物合成的新机制起作用。这种放线菌网产生的抗生素是铂霉素和Platecin加上一些次要的相关抗生素。 Platensimycin和Platencin具有针对抗生素抗性细菌的活性，例如耐甲氧脲葡萄球菌和万古霉素抗性肠球菌;他们在动物模型中也缺乏毒性。 Platensimycin还在小鼠模型中对糖尿病进行活动。我们一直有兴趣在化学定义的生产培养基中研究初级代谢产物对这些抗生素的产生的影响。在目前的工作中，我们测试了32个主要代谢物的效果。它们包括20个氨基酸，7个维生素和5个核酸衍生物。其中，只有L-天冬氨酸显示出抗生素生产的刺激。我们得出结论，天冬氨酸的刺激作用是由于其作为涉及的生物合成的前体的作用，这是3-氨基-2,4-二羟基苯甲酸部分的生物合成的起始点铂分子分子。

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    Falzone Maria; Crespo Emmanuel; Jones Klarissa; Khan Gulaba; Korn Victoria L.; Patel Amreen; Patel Mira; Patel Krishnaben; Perkins Carrie; Siddiqui Sana; Stenger Drew; Yu Eileen; Gelber Michael; Scheffler Robert; Nayda Vasyl; Ravin Ariela; Komal Ronica; Rudolf Jeffrey D.; Shen Ben; Gullo Vincent; Demain Arnold L.;

  • 作者单位

    Drew Univ Charles A Dana Res Inst RISE HS-330 Madison NJ 07940 USA;

    Drew Univ Charles A Dana Res Inst RISE HS-330 Madison NJ 07940 USA;

    Drew Univ Charles A Dana Res Inst RISE HS-330 Madison NJ 07940 USA;

    Drew Univ Charles A Dana Res Inst RISE HS-330 Madison NJ 07940 USA;

    Drew Univ Charles A Dana Res Inst RISE HS-330 Madison NJ 07940 USA;

    Drew Univ Charles A Dana Res Inst RISE HS-330 Madison NJ 07940 USA;

    Drew Univ Charles A Dana Res Inst RISE HS-330 Madison NJ 07940 USA;

    Drew Univ Charles A Dana Res Inst RISE HS-330 Madison NJ 07940 USA;

    Drew Univ Charles A Dana Res Inst RISE HS-330 Madison NJ 07940 USA;

    Drew Univ Charles A Dana Res Inst RISE HS-330 Madison NJ 07940 USA;

    Drew Univ Charles A Dana Res Inst RISE HS-330 Madison NJ 07940 USA;

    Drew Univ Charles A Dana Res Inst RISE HS-330 Madison NJ 07940 USA;

    Drew Univ Charles A Dana Res Inst RISE HS-330 Madison NJ 07940 USA;

    Drew Univ Charles A Dana Res Inst RISE HS-330 Madison NJ 07940 USA;

    Drew Univ Charles A Dana Res Inst RISE HS-330 Madison NJ 07940 USA;

    Drew Univ Charles A Dana Res Inst RISE HS-330 Madison NJ 07940 USA;

    Drew Univ Charles A Dana Res Inst RISE HS-330 Madison NJ 07940 USA;

    Scripps Res Inst Dept Chem Jupiter FL USA;

    Scripps Res Inst Dept Chem Jupiter FL USA;

    Drew Univ Charles A Dana Res Inst RISE HS-330 Madison NJ 07940 USA;

    Drew Univ Charles A Dana Res Inst RISE HS-330 Madison NJ 07940 USA;

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