Synthesis of unique spirocyclic orthoester-type derivatives of isothiazolo[4,3-d]pyrimidine nucleosides

Rovira Alexander R.; Tor Yitzhak

首页> 外文期刊>The Journal of Antibiotics: An International Journal >Synthesis of unique spirocyclic orthoester-type derivatives of isothiazolo[4,3-d]pyrimidine nucleosides

【24h】

Synthesis of unique spirocyclic orthoester-type derivatives of isothiazolo[4,3-d]pyrimidine nucleosides

机译：异噻唑洛[4,3-D]嘧啶核苷的独特螺环酯型衍生物的合成

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

A set of unique nucleoside analogs, containing 'spirocyclic orthoester-type' scaffolds, were synthesized from a common isothiazolo[4,3-d]pyrimidine-riboside precursor. The key reaction, using 1,2-di-heteroatomic nucleophiles (e.g., 1,2-ethandithiol) and BF3 center dot OEt2, converts an exocyclic imine into the spirocyclic analogs. The novel structural scaffold is confirmed through the use of one-and two-dimensional H-1 and C-13 NMR experiments.

机译：从一种常见的异噻唑并[4,3-d]嘧啶核苷前体合成了一组独特的核苷类似物，包含“螺环原酯型”支架。关键反应是使用1,2-二杂原子亲核试剂（例如，1,2-乙二硫醇）和BF3中心dot OEt2，将一个外环亚胺转化为螺环类似物。通过一维和二维H-1和C-13核磁共振实验证实了这种新型结构支架。

著录项

来源
《The Journal of Antibiotics: An International Journal》 |2018年第2期|共3页
作者
Rovira Alexander R.; Tor Yitzhak;
展开▼
作者单位

Univ Calif San Diego Dept Chem &

Biochem Pacific Hall 6228 9500 Gilman Dr La Jolla CA 92093 USA;

Univ Calif San Diego Dept Chem &

Biochem Pacific Hall 6228 9500 Gilman Dr La Jolla CA 92093 USA;

展开▼
收录信息
原文格式 PDF
正文语种 eng
中图分类药学;
关键词

相似文献

外文文献
中文文献
专利

1. Synthesis of new pyrimidine nucleoside derivatives with nitric oxide donors for antiviral activity [J] . Jing Bo Shi, Song Xu, Ya Ping Wang, 中国化学快报（英文版） . 2011,第008期
2. Highly Concise Synthesis of 3'-"Up"-ethynyl-5'-methylbicyclo-[3.1.0]-hexyl Purine and Pyrimidine Nucleoside Derivatives Using Rhodium(II) Carbenoid Cycloaddition and Highly Diastereoselective Grignard Reaction [J] . YANG Zunhua, JEONG Lak Shin, MOON Hyung Ryong, 中国化学（英文版） . 2009,第012期
3. Synthesis of unique spirocyclic orthoester-type derivatives of isothiazolo[4,3-d]pyrimidine nucleosides [J] . Rovira Alexander R., Tor Yitzhak The Journal of Antibiotics: An International Journal . 2018,第2期

机译：异噻唑洛[4,3-D]嘧啶核苷的独特螺环酯型衍生物的合成
4. Pyrimidinethione as a building block in heterocyclic synthesis: synthesis of pyrano[2,3-d]pyrimidine, chromeno[2,3-d]pyrimidine, pyrido[3 ',2 ':5,6]pyrano[2,3-b]pyridine, and pyrimido[5 ',4 ':5,6]pyrano[2,3-d]pyrimidine derivatives [J] . Reheim Mohamed Ahmed Mahmoud Abdel, Hafiz Ibrahim Saad Abdel, Elian Mohamed Ahmed Heterocyclic communications . 2016,第6期

机译：嘧啶硫酮作为杂环合成的基础：吡喃并[2,3-d]嘧啶，苯并[2,3-d]嘧啶，吡啶并[3'，2'：5,6]吡喃并[2,3-b]的合成吡啶和嘧啶基[5'，4'：5,6]吡喃并[2,3-d]嘧啶衍生物
5. Bicyclic furano-, pyrrolo-, and thiopheno[2,3-d] derivatives of pyrimidine nucleosides: Synthesis and antiviral properties [J] . Ivanov M.A., Aleksandrova L.A. Russian journal of bioorganic chemistry . 2013,第1期

机译：嘧啶核苷的双环呋喃-，吡咯并-和噻吩[2,3-d]衍生物：合成和抗病毒特性
6. Aqueous Phase Sonogashira Cross-Coupling Reaction in Synthesis of Bile Acid Conjugates of Purine and Pyrimidine Nucleosides and Nucleoside Triphosphates; Towards Bile Acid -Functionalized Nucleic Acids [C] . Satu Ikonen, Radek Pohl, Michal Hocek European Symposium on Organic Chemistry . 2009

机译：水相Sonogashira交叉偶联反应在嘌呤和嘧啶核苷的合成中合成，嘧啶核苷和核苷三磷酸盐;朝向胆汁酸 - 官能化核酸
7. I. Synthesis of saturated, DNA, and RNA spirocyclic-4,4-nonane nucleosides. II. Studies toward epoxy carbonate formation and the synthesis of suitable precursors. III. Methodological investigations involving the reactions of diazomethane with di-, tri-, and tetraketones. IV. Towards the total synthesis of salicifoline. [D] . Hartung, Ryan Eugene. 2005

机译：I.饱和，DNA和RNA螺环4，4-壬烷核苷的合成。二。研究环氧碳酸酯的形成和合适的前体的合成。三，方法学研究涉及重氮甲烷与二，三和四酮的反应。 IV。迈向水杨酸总合成。
8. Synthesis of unique spirocyclic orthoester-type derivatives of isothiazolo43-dpyrimidine nucleosides [O] . Alexander R Rovira, Yitzhak Tor -1

机译：异噻唑并43-d嘧啶核苷独特螺环原酸酯型衍生物的合成
9. Synthesis of unique spirocyclic orthoester-type derivatives of isothiazolo4,3-dpyrimidine nucleosides [O] . Alexander R Rovira, Yitzhak Tor 2017

机译：异噻唑洛4,3-D嘧啶核苷的独特螺环酯型衍生物的合成
10. Synthesis of Spirocyclic Derivatives Related to the Butyrophenone Neuroleptics [R] . Schiff, L. J., Mudd, P. J. 1972

机译：与丁酰苯神经抑制剂有关的螺环衍生物的合成

Synthesis of unique spirocyclic orthoester-type derivatives of isothiazolo[4,3-d]pyrimidine nucleosides

摘要

著录项

相似文献

相关主题

期刊订阅