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Synthesis of Spirocyclic Derivatives Related to the Butyrophenone Neuroleptics

机译：与丁酰苯神经抑制剂有关的螺环衍生物的合成

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A number of analogs related to haloperidol were synthesized and submitted for biological evaluation. In the course of the studies, two novel synthetic procedures were developed: The preparation of ketones by addition of acid chlorides to organocopper compounds; and The two-step preparation of secondary amines from tertiary benzyl amines having a divalent sulfur atom in the molecule. (Author)

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Schiff, L. J.; Mudd, P. J.;
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年度 1972
页码 p.1-22
总页数 22
原文格式 PDF
正文语种 eng
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关键词
Spiro compounds ; Ketones ; Synthesis(Chemistry) ; Copper compounds ; Metalorganic compounds ; Amines ; Organic sulfur compounds ; Halogenated hydrocarbons ; Fluorine compounds;

机译：螺环化合物;酮类;合成（化学）;铜化合物;金属有机化合物;胺类;有机硫化合物;卤代烃类;氟化合物;

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1. Synthesis of some new spirocyclic β-lactam and spirocyclic thiazolidin-4-one derivatives [J] . Hisham Abdallah Abd El-Monem Yosef, Nadia Ali Ahmed Elkanzi, Nesrin Mahmoud Morsy Mohamed European Journal of Chemistry . 2013,第3期

机译：一些新的螺环β-内酰胺和螺环噻唑烷-4-酮衍生物的合成
2. Simultaneous analysis of haloperidol, its three metabolites and two other butyrophenone-type neuroleptics by high performance liquid chromatography with dual ultraviolet detection. [J] . Higashi Y, Kitahara M, Fujii Y Biomedical Chromatography: An International Journal Devoted to Research in Chromatographic Methodologies and Their Applications in the Biosciences . 2006,第2期

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4. Efficient Synthesis of 7,6-Spirocyclic Imine and StereochemicalDetermination of Marine Toxin Spirolide Homologues [C] . Kou Minamino, Hiroshi Tsuchikawa, Michio Murata 日本化学会春季年会 . 2020

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6. Synthesis and Biological Evaluation of Spirocyclic Chromane Derivatives as a Potential Treatment of Prostate Cancer [O] . Li Feng, Shujia Yu, Hai Wang, 2021

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8. Compounds Derived from the Ring Expansion Reactions of 1-Benzyl-4-Piperidone and their Butyrophenone-Like Derivatives [R] . Schiff, L. J. 1972

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Synthesis of Spirocyclic Derivatives Related to the Butyrophenone Neuroleptics

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