Application ofMycobacterium smegmatisas a surrogate to evaluate drug leads againstMycobacterium tuberculosis

Lelovic Nada; Mitachi Katsuhiko; Yang Junshu; Lemieux Maddie R.; Ji Yinduo; Kurosu Michio

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Application ofMycobacterium smegmatisas a surrogate to evaluate drug leads againstMycobacterium tuberculosis

机译：分枝杆菌施霉菌的应用作为评估药物的替代药物引起分枝杆菌的蛋白酶

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Discovery of new anti-tuberculosis (TB) drugs is a time-consuming process due to the slow-growing nature ofMycobacterium tuberculosis(Mtb). A requirement of biosafety level 3 (BSL-3) facility for performing research associated with Mtb is another limitation for the development of TB drug discovery. In our screening of BSL-1Mycobacteriumspp. against a battery of TB drugs,M. smegmatis(ATCC607) exhibits good agreement with its drug susceptibility against the TB drugs under a low-nutrient culture medium (0.5% Tween 80 in Middlebrook 7H9 broth).M. smegmatis(ATCC607) enters its dormant form in 14 days under a nutrient-deficient condition (a PBS buffer), and shows resistance to a majority of TB drugs, but shows susceptibility to amikacin, capreomycin, ethambutol, and rifampicin (with high concentrations) whose activities against non-replicating (or dormant) Mtb were previously validated.

机译：由于结核分枝杆菌（Mtb）生长缓慢，发现新的抗结核（TB）药物是一个耗时的过程。生物安全3级（BSL-3）设施对结核分枝杆菌相关研究的要求是结核药物研发的另一个限制。在我们的BSL-1分枝杆菌筛选中。在低营养培养基（Middlebrook 7H9肉汤中0.5%吐温80）下，耻垢分枝杆菌（ATCC607）对一系列结核药物的敏感性与对结核药物的敏感性表现出良好的一致性。耻垢分枝杆菌（ATCC607）在营养缺乏的条件下（PBS缓冲液）在14天内进入休眠状态，对大多数结核药物表现出耐药性，但对丁胺卡那霉素、卷曲霉素、乙胺丁醇和利福平（高浓度）表现出易感性，其抗非复制（或休眠）结核分枝杆菌的活性此前已得到验证。

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《The Journal of Antibiotics: An International Journal》 |2020年第11期|共10页
作者
Lelovic Nada; Mitachi Katsuhiko; Yang Junshu; Lemieux Maddie R.; Ji Yinduo; Kurosu Michio;
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Univ Tennessee Coll Pharm Dept Pharmaceut Sci Hlth Sci Ctr 881 Madison Ave Memphis TN 38163;

Univ Tennessee Coll Pharm Dept Pharmaceut Sci Hlth Sci Ctr 881 Madison Ave Memphis TN 38163;

Univ Minnesota Dept Vet &

Biomed Sci 205 VSB 1971 Commonwealth Ave St Paul MN 55108 USA;

Univ Tennessee Coll Pharm Dept Pharmaceut Sci Hlth Sci Ctr 881 Madison Ave Memphis TN 38163;

Univ Minnesota Dept Vet &

Biomed Sci 205 VSB 1971 Commonwealth Ave St Paul MN 55108 USA;

Univ Tennessee Coll Pharm Dept Pharmaceut Sci Hlth Sci Ctr 881 Madison Ave Memphis TN 38163;

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正文语种 eng
中图分类药学;
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Application ofMycobacterium smegmatisas a surrogate to evaluate drug leads againstMycobacterium tuberculosis

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