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首页> 外文期刊>The Journal of Antibiotics: An International Journal >Isolation of nocobactin NAs as Notch signal inhibitors from Nocardia farcinica, a possibility of invasive evolution
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Isolation of nocobactin NAs as Notch signal inhibitors from Nocardia farcinica, a possibility of invasive evolution

机译：Nocobactin NAS作为来自Nocardia Farcinica的Notch信号抑制剂的分离，一种侵入性演化的可能性

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摘要

Notch signaling inhibitors with the potential of immune suppressor production by pathogenic bacteria for easy host infection were searched from extracts of Nocardia sp. Nocobactin NA-a (compound 1) and nocobactin NA-b (compound 2), which have been suggested as pathogenesis factors, were isolated from N. farcinica IFM 11523 isolated from the sputum of a Japanese patient with chronic bronchitis. Compounds 1 and 2 showed Notch inhibitory activities with IC50 values of 12.4 and 17.6 mu M, respectively. Compound 1 and 2 decreased of Notch1 protein, Notch intracellular domain, and hairy and enhancer of split 1, which is a Notch signaling target protein. In addition, compounds 1 and 2 showed cytotoxicity against mouse macrophage-like cell line RAW264.7 with IC50 values of 18.9 and 21.1 mu M, respectively. These results suggested that the Notch inhibitors production by pathogenic bacteria may increase pathogen infectivity.
机译：从诺卡氏菌（Nocardia sp.）的提取物中寻找具有致病性细菌产生免疫抑制因子的Notch信号抑制剂。从日本慢性支气管炎患者痰中分离的N.farcinica IFM 11523中分离出诺考巴菌素NA-a（化合物1）和诺考巴菌素NA-b（化合物2），它们被认为是致病因子。化合物1和2显示出Notch抑制活性，IC50值分别为12.4和17.6μM。化合物1和2降低了Notch1蛋白、Notch胞内结构域、以及Notch信号靶蛋白split 1的毛发和增强子的表达。此外，化合物1和2对小鼠巨噬细胞样细胞系RAW264具有细胞毒性。7，IC50值分别为18.9和21.1μM。这些结果表明，致病细菌产生的Notch抑制剂可能会增加病原体的传染性。

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