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首页> 外文期刊>Behavioural Brain Research: An International Journal >Behavioral effects of photothrombotic ischemic cortical injury in aged rats treated with the sedative-hypnotic GABAergic drug zopiclone.
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Behavioral effects of photothrombotic ischemic cortical injury in aged rats treated with the sedative-hypnotic GABAergic drug zopiclone.

机译：镇静催眠的GABA药佐匹克隆治疗老年大鼠的光血栓性缺血性皮层损伤的行为效应。

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摘要

Sedative-hypnotic drugs commonly used in the elderly may affect functional recovery following cerebrovascular events. Previous research has shown that prolonged exposure to diazepam can interfere with recovery of function and exaggerate tissue loss after brain injury. The present study evaluated the effect of zopiclone, a widely used hypnotic drug, on functional and histological outcome after cortical photothrombosis in aged rats, which might be particularly vulnerable to brain insults and inhibitory sedative-hypnotic drugs. Aged Wistar rats were treated with zopiclone at a dose of 3mg/kg (i.p., once a day) beginning 4 days before ischemia induction and continuing for 23 days. Sensorimotor recovery was assessed by a new ledged beam-walking test and spatial learning by the Morris water-maze. After a 7-day washout period all rats were administered a single dose of zopiclone (3mg/kg, i.p.) and retested. Infarct volumes were measured from nitroblue tetrazolium-stained sections at the end of the experiment.Beam-walking data showed that ischemic rats treated with zopiclone were not more impaired than untreated rats. Indeed, they showed fewer faults with the impaired hindlimb than ischemic controls on post-operative day 16. Water-maze performance was not affected by zopiclone. After the washout period a single dose of zopiclone did not worsen forelimb or hindlimb function, but seemed to improve performance in the water-maze test. Cortical infarct volumes were similar in ischemic controls and ischemic rats treated with zopiclone. In conclusion, zopiclone was not detrimental and even seemed to improve behavioral outcome without affecting ischemic damage in aged rats subjected to cortical photothrombosis.
机译：老年人常用的镇静催眠药可能会影响脑血管事件后的功能恢复。先前的研究表明，长时间暴露于地西epa可能会干扰脑损伤后功能的恢复并加剧组织的损失。本研究评估了广泛使用的催眠药佐匹克隆对老年大鼠皮质光血栓形成后功能和组织学结果的影响，这可能特别容易受到脑部伤害和抑制性镇静催眠药的影响。在缺血诱导前4天开始，以3mg / kg的剂量佐匹克隆治疗老年Wistar大鼠（i.p.，每天一次），并持续23天。感觉运动的恢复通过新的带束走行测试和莫里斯水迷宫进行的空间学习进行评估。在7天的清除期后，所有大鼠均接受单剂量的zopiclone（3mg / kg，腹腔注射）并重新测试。实验结束时从硝基蓝四唑鎓染色的切片中测量梗死体积。电子束行走数据显示，用佐匹克隆处理的缺血大鼠的受损程度不比未处理大鼠好。的确，术后第16天与后肢缺血对照相比，他们的后肢受损缺陷更少。水迷宫性能不受佐匹克隆的影响。冲洗期后，单剂量的佐匹克隆不会使前肢或后肢功能恶化，但似乎可以改善水迷宫测试的性能。在缺血对照组和用佐匹克隆治疗的缺血大鼠中，皮质梗死体积相似。总之，佐匹克隆对大脑皮层光血栓形成的老年大鼠无害，甚至可以改善行为预后而不影响缺血性损伤。

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