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Antiepileptic Drugs–Induced Enuresis in Children: An Overview

机译:抗癫痫药物诱发儿童胰岛素:概述

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Objective: To evaluate enuresis-induced antiepileptic drugs in children. Data Sources: A PubMed search (1917 to July 2020) was performed using the following keywords and associated medical subject headings: antiepileptic drugs, enuresis, pediatric population, drug-induced enuresis, and epilepsy. Study Selection and Data Extraction: The search was conducted to find the role of antiepileptic drugs–induced enuresis in children in studies published in English. Data Synthesis: Enuresis or bedwetting is an underreported adverse drug reaction of antiepileptic drugs. Owing to that fact, it is a condition that is outgrown with age and also could cause embarrassment. As antiepileptic drugs sometimes need to be taken for a long duration until epilepsy relapses, the occurrence of enuresis in this situation can be troublesome for both the child and the caretaker. Even though enuresis is proposed to have a significant effect on the child’s psychology, it is still considered to be a condition that is outgrown with age. This article includes a review of antiepileptic drugs reported to have caused enuresis in children. Conclusions: If a child develops enuresis as an adverse drug reaction, this adds further challenges to their life. A better understanding of this potential adverse effect may help prevent unwanted stress. Though the exact mechanisms are not known, the hypothesis generated is from the occurred cases, most of which relapsed when the drug was withdrawn. Considering the gravity of epilepsy in children, more detailed studies need to be conducted on this adverse effect to ensure a safe and effective treatment in children.
机译:目的:评价儿童遗尿诱发的抗癫痫药物。数据来源:PubMed搜索(1917年至2020年7月)使用以下关键词和相关医学主题标题进行:抗癫痫药物、遗尿、儿科人群、药物诱发遗尿和癫痫。研究选择和数据提取:在英文发表的研究中,进行搜索是为了发现抗癫痫药诱导的儿童遗尿症的作用。资料综合:遗尿或尿床是一种被低估的抗癫痫药物不良反应。由于这一事实,这是一种随着年龄增长而过时的疾病,也可能导致尴尬。由于抗癫痫药物有时需要服用很长一段时间,直到癫痫复发,在这种情况下,遗尿的发生对儿童和看护人来说都很麻烦。尽管人们认为遗尿症会对儿童的心理产生重大影响,但它仍然被认为是一种随着年龄增长而过时的疾病。这篇文章包括一篇关于抗癫痫药物引起儿童遗尿的综述。结论:如果儿童出现药物不良反应导致遗尿症,这会给他们的生活带来进一步的挑战。更好地理解这种潜在的不利影响可能有助于防止不必要的压力。虽然确切的机制尚不清楚,但所产生的假设来自已发生的病例,其中大多数病例在停药后复发。考虑到儿童癫痫的严重性,需要对这种不良反应进行更详细的研究,以确保儿童的安全有效治疗。

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