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首页> 外文期刊>The Journal of pharmacy technology: jPT : official publication of the Association of Pharmacy Technicians >A Comparison of Tertiary Drug Resources’ Consistency Regarding Drug-Drug Interactions of Adjunctive Analgesics
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A Comparison of Tertiary Drug Resources’ Consistency Regarding Drug-Drug Interactions of Adjunctive Analgesics

机译：三级药物资源对辅助镇痛药药物 - 药物相互作用的一致性比较

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Background: Health care providers routinely rely on tertiary drug information resources to affirm knowledge or proactively verify the safety and efficacy of medications. Though all patient care areas are affected, the reliability of these resources is perhaps nowhere as poignant as it is in high-acuity settings, including the emergency department and the intensive care unit. As providers seek to identify adjunctive analgesics for acute pain in these areas, they must be able to rely on the integrity to whichever resource their institution has granted access. Objective: To determine the congruency of drug-drug interaction information found on 3 tertiary drug resources. Methods: A drug-drug interaction analysis was conducted on Micromedex, Lexicomp, and Medscape. Adjunctive analgesics included dexmedetomidine and ketamine, which were compared with the intravenous opioid products morphine, fentanyl, and hydromorphone. Results: Significant discrepancies were appreciated with regard to the severity of drug-drug interactions. In addition, the heterogeneity in which reaction severity and likelihood are described by each respective resource makes direct comparisons difficult. Interaction warnings for dexmedetomidine and fentanyl included a “major interaction” from Micromedex, whereas Lexicomp did not identify a risk and Medscape only recommended increased monitoring on the grounds of respiratory and central nervous system depression. Conclusions: Health care providers must remain vigilant when reviewing tertiary drug information resources. Pharmacists possess the training and skills necessary to assist interdisciplinary medical teams in providing optimal patient care through evaluating and applying the information gleaned from these resources.
机译：背景：医疗保健提供者通常依赖三级药物信息资源来确认知识或主动验证药物的安全性和有效性。尽管所有患者护理领域都受到影响，但这些资源的可靠性可能远不如在高视力环境中（包括急诊科和重症监护室）那样令人痛心。当提供者寻求在这些区域识别用于急性疼痛的辅助止痛药时，他们必须能够依赖其机构授予的任何资源的完整性。目的：确定三级药物资源中药物相互作用信息的一致性。方法：在Micromedex、Lexicomp和Medscape上进行药物相互作用分析。辅助性镇痛药包括右美托咪定和氯胺酮，并与静脉注射阿片类药物吗啡、芬太尼和氢吗啡酮进行比较。结果：在药物相互作用的严重程度方面存在显著差异。此外，每个资源描述的反应严重性和可能性的异质性使得直接比较困难。右美托咪定和芬太尼的相互作用警告包括来自Micromedex的“主要相互作用”，而Lexicomp没有确定风险，Medscape仅建议以呼吸和中枢神经系统抑郁为理由加强监测。结论：卫生保健提供者在审查三级药物信息资源时必须保持警惕。药剂师拥有必要的培训和技能，通过评估和应用从这些资源中收集的信息，帮助跨学科医疗团队提供最佳的患者护理。

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