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首页> 外文期刊>The Journal of pharmacy technology: jPT : official publication of the Association of Pharmacy Technicians >Treatment of Chronic Refractory Cough in Adults: Focus on Neuromodulators and Other Therapeutic Modalities
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Treatment of Chronic Refractory Cough in Adults: Focus on Neuromodulators and Other Therapeutic Modalities

机译：治疗成人慢性耐火咳嗽：专注于神经调节剂和其他治疗方式

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Objective:To evaluate the literature and educate health care professionals about the different management options for chronic refractory cough (CRC).Data Sources:Searches were performed through MEDLINE (1966 to July 2020) using OVID and EBSCOhost and EMBASE (1947 to July 2020) using OVID. Search terms includedchronic cough, neurogenic cough, neuromodulators, chronic cough management, andchronic cough treatment. References of all relevant articles were further used to obtain additional articles.Study Selection and Data Extraction:This review includes articles in the English language and human trial literature. Twenty-three trials explored the use of oral neuromodulators in the management of CRC.Data Synthesis:CRC is a poorly understood disease that may have a complex neuropathic etiology. Oral neuromodulators, such as amitriptyline, baclofen, gabapentin, and pregabalin, continue to be the most commonly used agents for the management of CRC. Alternative pharmacological therapies such as botulinum toxin, anesthetic agents (benzonatate, lidocaine), and narcotic agents have efficacy data, and further research into effective doses and routes of administration is warranted. Alternative nonpharmacologic therapies more commonly used included speech pathology treatment.Conclusion:Several medication and alternative treatment interventions may be effective in managing CRC. Current studies used wide dosing and titration strategies, making it challenging to standardize therapy. No consistent method of assessing cough reflex was used between studies, as well as a lack of consistent randomization and small sample sizes. Additional research is needed to standardize treatment durations, optimum doses, and place in therapy of the available interventions in the management of CRC.
机译：目的：评估文献并教育医护人员关于慢性难治性咳嗽（CRC）的不同治疗方案。数据来源：通过使用OVID的MEDLINE（1966年至2020年7月）和使用OVID的EBSCOhost和EMBASE（1947年至2020年7月）进行搜索。搜索词包括慢性咳嗽、神经源性咳嗽、神经调节剂、慢性咳嗽管理和慢性咳嗽治疗。所有相关文章的参考文献被进一步用于获取其他文章。研究选择和数据提取：本综述包括英文和人类试验文献中的文章。23项试验探索了口服神经调节剂在大肠癌治疗中的应用。资料综合：大肠癌是一种了解甚少的疾病，可能有复杂的神经病因学。口服神经调节剂，如阿米替林、巴氯芬、加巴喷丁和普瑞巴林，仍然是治疗大肠癌最常用的药物。肉毒杆菌毒素、麻醉剂（苯甲酸盐、利多卡因）和麻醉剂等替代药理学疗法有疗效数据，需要对有效剂量和给药途径进行进一步研究。更常用的替代性非药物疗法包括言语病理学治疗。结论：多种药物和替代治疗干预可能是有效的管理大肠癌。目前的研究使用了广泛的剂量和滴定策略，这使得标准化治疗具有挑战性。研究之间没有使用一致的咳嗽反射评估方法，也缺乏一致的随机化和小样本。需要进行更多的研究，以标准化治疗持续时间、最佳剂量，并将CRC管理中可用的干预措施纳入治疗。

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