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首页> 外文期刊>The Journal of pharmacy technology: jPT : official publication of the Association of Pharmacy Technicians >The Physical Compatibility of Clinically Used Concentrations of Diltiazem Hydrochloride With Heparin Sodium
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The Physical Compatibility of Clinically Used Concentrations of Diltiazem Hydrochloride With Heparin Sodium

机译：盐酸肝素临床盐酸盐浓度的物理相容性

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Background: Acute treatment of atrial fibrillation often requires concomitant intravenous (IV) continuous infusions of unfractionated heparin and diltiazem. Concomitantly infusing these medications through the same IV line minimizes multiple IV sites. Diltiazem and heparin visual compatibility have been previously investigated but with limited drug dwell times and differing drug concentrations leading to inconsistent published results. Objective: To investigate the physical compatibility of diltiazem hydrochloride at concentrations of 5 and 1 mg/mL combined with an equal volume of heparin sodium 100 units/mL. Methods: Using a 0.22-mu m filter, 15 mL of heparin sodium were placed into a polyvinyl chloride infusion bag followed by 15 mL of either diltiazem hydrochloride 5 or 1 mg/mL. Admixtures were prepared in triplicate. Each admixture was investigated for visual precipitation, spectrophotometric absorbance, and pH change at baseline and 1, 5, 8, and 24 hours after mixing. Physical incompatibility was determined by visual observation, increased spectrophotometric absorbance, and demonstrative pH changes. Results: Each diltiazem 5 mg/mL admixture exhibited a slight haze and enhanced absorbance readings indicating turbidity while none revealed a demonstrative pH change. None of the diltiazem 1 mg/mL assessments revealed visual precipitation or suggested turbidity. Only one pH reading at 5 hours revealed a demonstrative change from baseline. Conclusions: Our findings indicate that infusing diltiazem hydrochloride 5 mg/mL with heparin sodium 100 units/mL in the same IV line cannot be advocated. In contrast, our findings suggest that heparin sodium 100 units/mL infused with diltiazem hydrochloride 1 mg/mL is physically compatible but chemical stability was not assessed.
机译：背景：心房颤动的急性治疗通常需要同时静脉持续输注普通肝素和地尔硫卓。同时通过同一条静脉输注线输注这些药物，可以最大限度地减少多个静脉注射部位。地尔硫卓和肝素的视觉相容性之前已有研究，但药物停留时间有限，药物浓度不同，导致公布的结果不一致。目的：研究浓度为5和1mg/mL的盐酸地尔硫卓与等体积肝素钠（100单位/mL）的物理相容性。方法：使用0.22μm过滤器，将15ml肝素钠放入聚氯乙烯输液袋中，然后加入15ml盐酸地尔硫卓5或1mg/mL。制备三份外加剂。在基线和混合后1、5、8和24小时，对每种混合物进行目视沉淀、分光光度吸光度和pH变化研究。物理不相容性通过目视观察、增加分光光度吸光度和显示pH值变化来确定。结果：每种5 mg/mL的地尔硫卓混合液都显示出轻微的浑浊，吸光度读数增强，表明混浊，而没有一种显示出明显的pH值变化。1 mg/mL的地尔硫卓评估均未显示可见沉淀或浑浊。在5小时内，只有一个pH值读数显示出与基线相比的明显变化。结论：我们的研究结果表明，不能提倡在同一条静脉线上注射5 mg/mL盐酸地尔硫卓和100单位/mL肝素钠。相比之下，我们的研究结果表明，注入1 mg/mL盐酸地尔硫卓的100单位/mL肝素钠在物理上是相容的，但没有评估化学稳定性。

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