• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>The Journal of Nutritional Biochemistry >Nutritional modulation of leptin expression and leptin action in obesity and obesity-associated complications
【24h】

Nutritional modulation of leptin expression and leptin action in obesity and obesity-associated complications

机译：瘦素表达和瘦素作用在肥胖症和肥胖相关并发症中的营养调节

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

In obesity, an elevated accumulation and dysregulation of adipose tissue, due to an imbalance between energy intake and energy expenditure, usually coexists with the loss of responsiveness to leptin in central nervous system, and subsequently with hyperleptinemia. Leptin, a peptide hormone mainly produced by white adipose tissue, regulates energy homeostasis by stimulating energy expenditure and inhibiting food intake. Human obesity is characterized by increased plasma leptin levels, which have been related with different obesity-associated complications, such as chronic inflammatory state (risk factor for diabetes, cardiovascular and autoimmune diseases), as well as infertility and different types of cancer. Besides, leptin is also produced by placenta, and high leptin levels during pregnancy may be related with some pathological conditions such as gestational diabetes. This review focuses on the current insights and emerging concepts on potentially valuable nutrients and food components that may modulate leptin metabolism. Notably, several dietary food components, such as phenols, peptides, and vitamins, are able to decrease inflammation and improve leptin sensitivity by upor down-regulation of leptin signaling molecules. On the other hand, some food components, such as saturated fatty acids may worsen chronic inflammation increasing the risk for pathological complications. Future research into nutritional mechanisms that restore leptin metabolism and signals of energy homeostasis may inspire new treatment options for obesity-related disorders. (c) 2020 Published by Elsevier Inc.
机译：在肥胖症中，由于能量摄入和能量消耗之间的不平衡，脂肪组织的积累和调节异常增加，通常与中枢神经系统对瘦素的反应性丧失共存，随后又与高瘦素血症共存。瘦素是一种主要由白色脂肪组织产生的肽类激素，通过刺激能量消耗和抑制食物摄入来调节能量平衡。人类肥胖的特点是血浆瘦素水平升高，这与不同的肥胖相关并发症有关，如慢性炎症状态（糖尿病、心血管疾病和自身免疫性疾病的风险因素），以及不孕症和不同类型的癌症。此外，瘦素也由胎盘产生，妊娠期瘦素水平高可能与妊娠期糖尿病等疾病有关。本文综述了目前对可能调节瘦素代谢的潜在有价值的营养素和食物成分的认识和新概念。瘦素和瘦素可以通过调节食物中的瘦素和酚类物质来改善食物的敏感性。另一方面，一些食物成分，如饱和脂肪酸，可能会加重慢性炎症，增加病理并发症的风险。未来对恢复瘦素代谢和能量稳态信号的营养机制的研究可能会激发肥胖症相关疾病的新治疗选择。（c） 2020年由爱思唯尔公司出版。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号