Differential behavioral and neurochemical effects of cocaine after early exposure to methylphenidate in an animal model of attention deficit hyperactivity disorder.

Augustyniak PN; Kourrich S; Rezazadeh SM; Stewart J; Arvanitogiannis A

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Differential behavioral and neurochemical effects of cocaine after early exposure to methylphenidate in an animal model of attention deficit hyperactivity disorder.

机译：在注意缺陷多动障碍动物模型中，可卡因在早期暴露于哌醋甲酯后的差异行为和神经化学作用。

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We used a putative animal model of attention deficit hyperactivity disorder (ADHD), the SHR rat, to examine the effects of repeated exposure to methylphenidate (MPH; Ritalin) during the pubertal period on cocaine-induced conditioned place preference and dopamine (DA) levels in the nucleus accumbens (NAc) in adulthood. Our results indicate that early exposure to methylphenidate diminishes sensitivity to the incentive properties of cocaine in adulthood, but it does so without altering the response of the mesolimbic dopamine system.

机译：我们使用了注意力缺陷多动障碍（ADHD）的假定动物模型SHR大鼠，研究了青春期反复接触哌醋甲酯（MPH;利他林）对可卡因诱发的条件性位置偏爱和多巴胺（DA）水平的影响在成年期伏伏核（NAc）中我们的结果表明，尽早暴露于哌醋甲酯对成年期可卡因的刺激特性的敏感性下降，但这样做不会改变中脑边缘多巴胺系统的反应。

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来源
《Behavioural Brain Research: An International Journal》 |2006年第2期|共4页
作者
Augustyniak PN; Kourrich S; Rezazadeh SM; Stewart J; Arvanitogiannis A;
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正文语种 eng
中图分类基础医学;
关键词
Methylphenidate; Cocaine; Child attention deficit disorder; Models; Animal; 哌醋甲酯; 可卡因;

机译：Methylphenidate;Cocaine;Child attention deficit disorder;Models;Animal;哌醋甲酯;可卡因;

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1. Differential behavioral and neurochemical effects of cocaine after early exposure to methylphenidate in an animal model of attention deficit hyperactivity disorder. [J] . Augustyniak PN, Kourrich S, Rezazadeh SM, Behavioural Brain Research: An International Journal . 2006,第2期

机译：在注意缺陷多动障碍动物模型中，可卡因在早期暴露于哌醋甲酯后的差异行为和神经化学作用。
2. Effects of OROS methylphenidate on academic, behavioral, and cognitive tasks in children 9 to 12 years of age with attention-deficit/hyperactivity disorder. [J] . Murray DW, Childress A, Giblin J, Clinical Pediatrics . 2011,第4期

机译：OROS哌醋甲酯对9-12岁患有注意缺陷/多动障碍的儿童的学业，行为和认知任务的影响。
3. Academic, behavioral, and cognitive effects of OROS(R) methylphenidate on older children with attention-deficit/hyperactivity disorder. [J] . Wigal SB, Wigal T, Schuck S, Journal of child and adolescent psychopharmacology . 2011,第2期

机译：OROS（R）哌醋甲酯对患有注意力缺陷/多动障碍的大龄儿童的学术，行为和认知影响。
4. The Effects of Maternal Cadmium Exposure and Attention Deficit Hyperactivity Disorder in Children 6 Years of Age [C] . Woo Sung Kim, Youn-Hee Urn, Bung-Nyun Kim, Joint annual meeting of the International Society of Exposure Science and the International Society for Environmental Epidemiology . 2018

机译：母体镉暴露和注意缺陷多动障碍对6岁儿童的影响
5. Effects of response cost, bibliotherapy and academic tutoring on attentional behavior, achievement, work productivity, accuracy, and self-esteem in children with attention deficit hyperactivity disorder. [D] . Turner, Becky Louise Beno. 1996

机译：响应成本，书目治疗和学术辅导对注意力不足多动障碍儿童注意行为，成就，工作效率，准确性和自尊的影响。
6. The differential effects of teacher and peer attention on the disruptive classroom behavior of three children with a diagnosis of attention deficit hyperactivity disorder. [O] . J Northup, C Broussard, K Jones, 1995

机译：老师和同伴注意对三名诊断为注意缺陷多动障碍的孩子的破坏性课堂行为的不同影响。
7. Long-term effects of stimulant exposure on cerebral blood flow response to methylphenidate and behavior in attention-deficit hyperactivity disorder. [O] . Schrantee A., Bouziane C., Bron E.E., 2017

机译：长期暴露于兴奋剂对脑血流对哌醋甲酯反应和行为异常的影响。

Differential behavioral and neurochemical effects of cocaine after early exposure to methylphenidate in an animal model of attention deficit hyperactivity disorder.

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