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首页> 外文期刊>The journal of sexual medicine >Association Between Opioid Use and Risk of Erectile Dysfunction: A Systematic Review and Meta-Analysis
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Association Between Opioid Use and Risk of Erectile Dysfunction: A Systematic Review and Meta-Analysis

机译：阿片类药物使用与勃起功能障碍风险的关联：系统评价和荟萃分析

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摘要

Abstract Background Opioid analgesics have been widely used to relieve chronic pain conditions; however, a connection between opioid analgesic administration and increased susceptibility to erectile dysfunction (ED) has been hypothesized. Aim To evaluate whether opioid use was a risk factor for ED in a systematic review and meta-analysis. Methods The PubMed, Cochrane Library, and Embase databases were searched to identify eligible studies concerning opioid use and risk of ED from inception to April 2017. The association between opioid use and risk of ED was summarized using the relative risk with 95% CI. Sensitivity analyses were conducted to assess potential bias. The Begg and Egger tests were used for publication bias analysis. The GRADE evidence profile tool was used to assess the quality of the evidence. Outcomes The overall combined risk estimates for the effect of opioid use on ED were calculated using a random-effects model. Results This meta-analysis included 8,829 men (mean age?= 41.6 years) from 10 studies, 2,456 of whom received opioid management (duration of intervention?= 4 months to 9.5 years). Pooled results demonstrated that the use of opioids was significantly associated with an increased risk of ED (relative risk?= 1.96, 95% CI?=?1.66–2.32, P Clinical Implications We found that men with opioid use had a significantly increased prevalence of ED, which suggests that patients and clinicians should be aware of the potential role played by opioid administration in the development of ED. Strengths and Limitations This is the first meta-analysis performed to describe the relation between opioid use and ED risk based on all available epidemiologic studies. However, the direction of causality between opioid use and risk of ED should be interpreted with caution because most included studies used a cross-sectional design. Conclusion Evidence from the included observational studies indicated that men with opioid use had a significantly increased risk of ED. Further randomized controlled trials are still needed to confirm this relation. Zhao S, Deng T, Luo L, et?al. Association Between Opioid Use and Risk of Erectile Dysfunction: A Systematic Review and Meta-Analysis. J Sex Med 2017;14:1209–1219.
机译：摘要背景阿片类镇痛药已广泛用于缓解慢性疼痛；然而，阿片类镇痛药的服用与勃起功能障碍（ED）易感性的增加之间存在联系。目的通过系统回顾和荟萃分析，评估阿片类药物的使用是否是ED的危险因素。方法检索PubMed、Cochrane图书馆和Embase数据库，以确定从开始到2017年4月有关阿片类药物使用和ED风险的合格研究。阿片类药物使用与ED风险之间的关联通过95%可信区间的相对风险进行总结。进行敏感性分析以评估潜在偏差。Begg和爱格测试用于发表偏倚分析。等级证据档案工具用于评估证据的质量。结果使用随机效应模型计算阿片类药物使用对ED影响的总体综合风险估计。结果该荟萃分析包括10项研究中的8829名男性（平均年龄？=41.6岁），其中2456人接受了阿片类药物治疗（干预持续时间？=4个月至9.5年）。汇总结果表明，使用阿片类药物与ED风险增加显著相关（相对风险？=1.96，95%可信区间？=1.66–2.32，P临床意义我们发现，使用阿片类药物的男性ED患病率显著增加，这表明患者和临床医生应该意识到阿片类药物在ED发展中的潜在作用。优势和局限性这是首次进行荟萃分析，以描述阿片类药物与ED之间的关系根据所有可用的流行病学研究，使用和降低风险。然而，阿片类药物使用与ED风险之间因果关系的方向应谨慎解释，因为大多数纳入研究采用了横断面设计。结论纳入的观察性研究的证据表明，使用阿片类药物的男性患ED的风险显著增加。仍需进一步的随机对照试验来证实这一关系。赵S，邓T，罗L，等等？阿片类药物使用与勃起功能障碍风险之间的关联：一项系统综述和荟萃分析。J Sex Med 2017；14:1209–1219.

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  • 来源
    《The journal of sexual medicine》 |2017年第10期|共11页
  • 作者

    Shankun Zhao; Tuo Deng; Lianmin Luo; Jiamin Wang; Ermao Li; Luhao Liu; Futian Li; Jintai Luo; Zhigang Zhao;

  • 作者单位

    Department of Urology and Andrology Minimally Invasive Surgery Center Guangdong Provincial Key;

    Department of Urology and Andrology Minimally Invasive Surgery Center Guangdong Provincial Key;

    Department of Urology and Andrology Minimally Invasive Surgery Center Guangdong Provincial Key;

    Department of Urology and Andrology Minimally Invasive Surgery Center Guangdong Provincial Key;

    Department of Urology and Andrology Minimally Invasive Surgery Center Guangdong Provincial Key;

    Department of Urology and Andrology Minimally Invasive Surgery Center Guangdong Provincial Key;

    Department of Urology and Andrology Minimally Invasive Surgery Center Guangdong Provincial Key;

    Department of Urology and Andrology Minimally Invasive Surgery Center Guangdong Provincial Key;

    Department of Urology and Andrology Minimally Invasive Surgery Center Guangdong Provincial Key;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 性卫生;
  • 关键词

    Opioid; Erectile Dysfunction; Systematic Review; Meta-Analysis;

    机译：阿片类化合物;勃起功能障碍;系统评价;META分析;

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