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首页> 外文期刊>Annals of nuclear medicine >Usefulness of rate of increase in SPECT counts in one-day method of N-isopropyl-4-iodoamphetamine (123I) SPECT studies at rest and after acetazolamide challenge using a method for estimating time-dependent distribution at rest.
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Usefulness of rate of increase in SPECT counts in one-day method of N-isopropyl-4-iodoamphetamine (123I) SPECT studies at rest and after acetazolamide challenge using a method for estimating time-dependent distribution at rest.

机译：N-异丙基-4-碘安非他明（123I）的单日研究在静息时和乙酰唑胺激发后使用静息时间分布估计方法进行SPECT计数增加率的有用性。

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OBJECTIVE: When N-isopropyl-4-iodoamphetamine ((123)I-IMP) single-photon emission computed tomography (SPECT) studies at rest and after acetazolamide (ACZ) challenge are conducted in a day, the time-dependent change in IMP in the brain at rest should be estimated accurately. We devised the method and investigated whether our one-day method for measuring the rate of increase in SPECT counts allowed reduction in the acquisition time. METHODS: Sequential, 5-min SPECT scans were performed. We estimated the time-dependent change in the brain using the change in slopes of two linear equations derived from the first three SPECT counts. For the one-day method, ACZ was administered 15 min or 20 min after IMP administration. The second IMP was administered 10 min after ACZ administration. RESULTS: Time-dependent changes in the brain were classified into 13 patterns when estimation was started at 5 min after IMP administration and 6 patterns when estimation was started at 10 min, and fitting coefficients were determined. The correlation between actual measurements at 37.5 min and estimates was high with a correlation coefficient of 0.99 or greater. Rates of increase obtained from 20-min data were highly correlated with those obtained from 15-min or 10-min data (r = 0.97 or greater). In patients with unilateral cerebrovascular disease, the rate of increase on the unaffected side was 44.4 +/- 10.9% when ACZ was administered 15 min later and 48.0 +/- 16.0% when ACZ was administered 20 min later, and the rates of increase with different timings of administration were not significantly different. CONCLUSIONS: The examination time may be reduced from 50 min to 45 min or 40 min as needed. The rate of increase was not influenced by the time frame for determination or the timing of ACZ administration. These findings suggest that our estimation method is accurate and versatile.
机译：目的：在一天中进行静态和乙酰唑胺（ACZ）攻击后进行N-异丙基-4-碘苯丙胺（（123）I-IMP）单光子发射计算机断层扫描（SPECT）研究时，IMP随时间的变化大脑中的静止状态应该准确估计。我们设计了该方法，并研究了我们的单日测量SPECT计数增加速率的方法是否可以减少采集时间。方法：进行了连续5分钟的SPECT扫描。我们使用从前三个SPECT计数得出的两个线性方程的斜率变化来估计大脑的时间依赖性变化。对于一日法，在IMP给药后15分钟或20分钟给药ACZ。 ACZ给药后10分钟，第二次IMP给药。结果：IMP给药后5分钟开始估算时，大脑随时间的变化分为13种模式，10分钟开始估算时有6种模式，并确定了拟合系数。 37.5分钟的实际测量值与估计值之间的相关性很高，相关系数为0.99或更大。从20分钟的数据获得的增长率与从15分钟或10分钟的数据获得的增长率高度相关（r = 0.97或更高）。在单侧脑血管疾病患者中，ACZ给药15分钟后未受影响一侧的增加率为44.4 +/- 10.9％，ACZ给药20分钟后未受影响的一侧的增加率为48.0 +/- 16.0％，不同的给药时间没有显着差异。结论：检查时间可根据需要从50分钟减少到45分钟或40分钟。增加的速率不受测定时间范围或ACZ施用时间的影响。这些发现表明我们的估计方法是准确和通用的。

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