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首页> 外文期刊>The journals of gerontology.Series A. Biological sciences and medical sciences >Is Cortical Activation During Walking Different Between Parkinson's Disease Motor Subtypes?
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Is Cortical Activation During Walking Different Between Parkinson's Disease Motor Subtypes?

机译：在帕金森氏病电机亚型之间行走时的皮质激活是什么？

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摘要

Parkinson's disease (PD) is often classified into tremor dominant (TD) and postural instability gait disorder (PIGD) subtypes. Degeneration of subcortical/cortical pathways is different between PD subtypes, which leads to differences in motor behavior. However, the influence of PD subtype on cortical activity during walking remains poorly understood. Therefore, we aimed to investigate the influence of PD motor subtypes on cortical activity during unobstructed walking and obstacle avoidance. Seventeen PIGD and 19 TD patients performed unobstructed walking and obstacle avoidance conditions. Brain activity was measured using a mobile functional near-infrared spectroscopy-electroencephalography (EEG) systems, and gait parameters were analyzed using an electronic carpet. Concentrations of oxygenated hemoglobin (HbO(2)) of the prefrontal cortex (PFC) and EEG absolute power from alpha, beta, and gamma bands in FCz, Cz, CPz, and Oz channels were calculated. These EEG channels correspond to supplementary motor area, primary motor cortex, posterior parietal cortex, and visual cortex, respectively. Postural instability gait disorder patients presented higher PFC activity than TD patients, regardless of the walking condition. Tremor dominant patients presented reduced beta power in the Cz channel during obstacle avoidance compared to unobstructed walking. Both TD and PIGD patients decreased alpha and beta power in the FCz and CPz channels. In conclusion, PIGD patients need to recruit additional cognitive resources from the PFC for walking. Both TD and PIGD patients presented changes in the activation of brain areas related to motor/sensorimotor areas in order to maintain balance control during obstacle avoidance, being that TD patients presented further changes in the motor area (Cz channel) to avoid obstacles.
机译：帕金森病（PD）通常分为震颤主导型（TD）和姿势不稳定型步态障碍（PIGD）亚型。皮质下/皮质通路的退化在PD亚型之间是不同的，这导致运动行为的差异。然而，PD亚型对行走过程中皮层活动的影响仍知之甚少。因此，我们旨在研究PD运动亚型对无障碍行走和避障期间皮层活动的影响。17名PIGD和19名TD患者在无障碍行走和避障条件下行走。使用移动功能性近红外光谱脑电图（EEG）系统测量大脑活动，并使用电子地毯分析步态参数。计算前额叶皮质（PFC）的含氧血红蛋白（HbO（2））浓度以及FCz、Cz、CPz和Oz通道中α、β和γ带的EEG绝对功率。这些脑电图通道分别对应于辅助运动区、初级运动皮质、后顶叶皮质和视觉皮质。无论行走条件如何，姿势不稳定步态障碍患者的PFC活性均高于TD患者。与无障碍行走相比，以震颤为主的患者在避障期间Cz通道的β功率降低。TD和PIGD患者都降低了FCz和CPz通道的α和β功率。总之，PIGD患者需要从PFC招募额外的认知资源用于行走。TD和PIGD患者都表现出与运动/感觉运动区域相关的大脑区域激活的变化，以便在避障期间保持平衡控制，因为TD患者表现出运动区域（Cz通道）的进一步变化，以避免障碍。

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