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首页> 外文期刊>The journals of gerontology.Series A. Biological sciences and medical sciences >Testing Proposed Quantifications of Biological Aging in Taiwanese Older Adults
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Testing Proposed Quantifications of Biological Aging in Taiwanese Older Adults

机译：测试台湾老年人生物老化量化量

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Quantification of biological aging is of interest in gerontology as a means to surveil aging rates in the population and to evaluate the effects of interventions to increase healthy life span. Analysis of proposed methods to quantify biological aging has focused on samples of midlife or mixed-age adults in the West. Research is needed to test whether quantifications of biological aging can differentiate aging rates among older adults and if quantifications of biological aging developed in Western samples can differentiate aging rates in non-Western populations. We conducted analysis of Klemera-Doubal method (KDM) Biological Age and homeostatic dysregulation measures of biological aging developed in the U.S. NHANES and tested in a sample of older Taiwanese adults in the Social Environment and Biomarkers of Aging Study. We conducted analysis of physical and cognitive function and mortality, comparing quantifications of biological aging to a biomarker index based on norms within our analysis sample and to participants' ratings of their own health. Results showed that quantifications of biological aging (a) predicted differences in physical and cognitive function and in mortality risk among Taiwanese older adults and (b) performed as well as a traditional biomarker index and participant self-rated health for prediction of these outcomes.
机译：在老年医学中，生物老化的量化是一种监测人口老龄化率和评估干预措施对延长健康寿命的影响的手段。对量化生物老化的拟议方法的分析主要集中在西方中年或混合年龄成年人的样本上。需要进行研究，以测试生物老化的量化是否能够区分老年人的老化率，以及西方样本中的生物老化量化是否能够区分非西方人群的老化率。我们对美国NHANES开发的Klemera-Doubal方法（KDM）生物年龄和生物老化的稳态失调措施进行了分析，并在老龄化研究的社会环境和生物标记物中对台湾老年人样本进行了测试。我们对身体和认知功能以及死亡率进行了分析，将生物老化的量化与基于分析样本中规范的生物标志物指数以及参与者对自身健康的评级进行了比较。结果显示，生物老化的量化（a）预测了台湾老年人的身体和认知功能以及死亡风险的差异，（b）与传统的生物标志物指数和参与者自评健康指数一样，可以预测这些结果。

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