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首页> 外文期刊>The journals of gerontology.Series A. Biological sciences and medical sciences >High Intensity Interval Training Improves Physical Performance and Frailty in Aged Mice
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High Intensity Interval Training Improves Physical Performance and Frailty in Aged Mice

机译：高强度间隔训练改善了老年小鼠的物理性能和体弱

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摘要

Sarcopenia and frailty are highly prevalent in older individuals, increasing the risk of disability and loss of independence. High intensity interval training (HIIT) may provide a robust intervention for both sarcopenia and frailty by achieving both strength and endurance benefits with lower time commitments than other exercise regimens. To better understand the impacts of HIIT during aging, we compared 24-month-old C57BL/6J sedentary mice with those that were administered 10-minute uphill treadmill HIIT sessions three times per week over 16 weeks. Baseline and end point assessments included body composition, physical performance, and frailty based on criteria from the Fried physical frailty scale. HIIT-trained mice demonstrated dramatic improvement in grip strength (HIIT 10.9% vs ?3.9% in sedentary mice), treadmill endurance (32.6% vs ?2.0%), and gait speed (107.0% vs 39.0%). Muscles from HIIT mice also exhibited greater mass, larger fiber size, and an increase in mitochondrial biomass. Furthermore, HIIT exercise led to a dramatic reduction in frailty scores in five of six mice that were frail or prefrail at baseline, with four ultimately becoming nonfrail. The uphill treadmill HIIT exercise sessions were well tolerated by aged mice and led to performance gains, improvement in underlying muscle physiology, and reduction in frailty.
机译：肌肉减少症和虚弱在老年人中非常普遍，增加了残疾和丧失独立性的风险。与其他运动方案相比，高强度间歇训练（HIIT）可以在较短的时间内获得力量和耐力的益处，从而为肌肉减少症和虚弱症提供强有力的干预。为了更好地了解HIIT在衰老过程中的影响，我们比较了24个月大的C57BL/6J久坐小鼠和在16周内每周三次在跑步机上进行10分钟HIIT治疗的小鼠。根据Fried身体虚弱量表的标准，基线和终点评估包括身体成分、身体表现和虚弱。经过HIIT训练的小鼠在握力（HIIT 10.9%比久坐小鼠的3.9%）、跑步机耐力（32.6%比2.0%）和步态速度（107.0%比39.0%）方面表现出显著的改善。HIIT小鼠的肌肉也表现出更大的质量、更大的纤维大小和线粒体生物量的增加。此外，HIIT运动导致6只在基线检查时处于虚弱或预疲劳状态的小鼠中有5只的虚弱评分显著降低，其中4只最终成为非疲劳状态。老年小鼠对上坡跑步机HIIT运动有良好的耐受性，并能提高表现，改善潜在的肌肉生理，减少虚弱。

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