• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>The journals of gerontology.Series A. Biological sciences and medical sciences >Associations of Plasma Folate and Vitamin B-6 With Blood DNA Methylation Age: An Analysis of One-Carbon Metabolites in the VA Normative Aging Study
【24h】

Associations of Plasma Folate and Vitamin B-6 With Blood DNA Methylation Age: An Analysis of One-Carbon Metabolites in the VA Normative Aging Study

机译：血浆叶酸和维生素B-6与血液DNA甲基化的关联：VA规范老化研究中的单碳代谢物分析

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

One-carbon metabolism is an important contributor to aging-related diseases; nevertheless, relationships of one-carbon metabolites with novel DNA methylation-based measures of biological aging remain poorly characterized. We examined relationships of one-carbon metabolites with 3 DNA methylation-based measures of biological aging: DNAm Age, Grim Age, and Pheno Age. We measured plasma levels of 4 common one-carbon metabolites (vitamin B-6 vitamin B-12, folate, and homocysteine) in 715 VA Normative Aging Study participants with at least 1 visit between 1999 and 2008 (observations = 1153). DNA methylation age metrics were calculated using the Human Methylation 450 Bead Chip. We utilized Bayesian Kernel Machine Regression models adjusted for chronological age, lifestyle factors, age-related diseases, and study visits to determine metabolites important to the aging outcomes. Bayesian Kernel Machine Regression models allowed for the estimation of the relationships of single metabolites and the cumulative metabolite mixture with methylation age. Log vitamin B(6 )was selected as important to PhenoAge (beta = -1.62 years, 95% CI: -2.28, -0.96). Log folate was selected as important to GrimAge (beta = 0.75 years, 95% CI: 0.41, 1.09) and PhenoAge (beta = 1.62 years, 95% CI: 0.95, 2.29). Compared to a model where each metabolite in the mixture is set to its 50th percentile, the log cumulative mixture with each metabolite at its 30th (beta = -0.13 years, 95% CI: -0.26, -0.005) and 40th percentile (beta = -0.06 years, 95% CI: -0.11, -0.005) was associated with decreased GrimAge. Our results provide novel characterizations of the relationships between one-carbon metabolites and DNA methylation age in a human population study. Further research is required to confirm these findings and establish their generalizability.
机译：一是碳代谢是导致衰老相关疾病的重要因素；然而，单碳代谢产物与新的基于DNA甲基化的生物老化指标之间的关系仍然缺乏特征。我们研究了单碳代谢物与三种基于DNA甲基化的生物衰老指标的关系：DNAm年龄、严酷年龄和物候年龄。在1999年至2008年期间，我们对715名VA规范性衰老研究参与者进行了至少一次随访，测量了4种常见单碳代谢产物（维生素B-6、维生素B-12、叶酸和同型半胱氨酸）的血浆水平（观察值=1153）。使用人类甲基化450珠芯片计算DNA甲基化年龄指标。我们利用贝叶斯核机器回归模型，根据实际年龄、生活方式因素、年龄相关疾病和研究访问进行调整，以确定对衰老结果重要的代谢物。贝叶斯核机器回归模型允许估计单一代谢物和累积代谢物混合物与甲基化年龄的关系。对数维生素B（6）被选为对物候期很重要（β=1.62岁，95%置信区间：-2.28，-0.96）。对数叶酸被选为对GrimAge（β=0.75岁，95%可信区间：0.41,1.09）和物候期（β=1.62岁，95%可信区间：0.95,2.29）的重要指标。与将混合物中的每种代谢物设置为其第50个百分位的模型相比，每种代谢物在其第30个百分位（β=-0.13年，95%置信区间：-0.26，-0.005）和第40个百分位（β=-0.06年，95%置信区间：-0.11，-0.005）的对数累积混合物与减少的皱纹有关。我们的结果为一项人类群体研究中单碳代谢产物与DNA甲基化年龄之间的关系提供了新的表征。需要进一步研究来证实这些发现，并确定其普遍性。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号