• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>The journals of gerontology.Series A. Biological sciences and medical sciences >Acute, Exercise-Induced Alterations in Cytokines and Chemokines in the Blood Distinguish Physically Active and Sedentary Aging
【24h】

Acute, Exercise-Induced Alterations in Cytokines and Chemokines in the Blood Distinguish Physically Active and Sedentary Aging

机译：急性，运动诱导的细胞因子和趋化因子的改变在血液中区分身体活性和久坐的衰老

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Aging results in a chronic, proinflammatory state which can promote and exacerbate age-associated diseases. In contrast, physical activity in older adults improves whole body health, protects against disease, and reduces inflammation, but the elderly are less active making it difficult to disentangle the effects of aging from a sedentary lifestyle. To interrogate this interaction, we analyzed peripheral blood collected at rest and postexercise from 68 healthy younger and older donors that were either physically active aerobic exercisers or chronically sedentary. Subjects were profiled for 44 low-abundance cytokines, chemokines, and growth factors in peripheral blood. At rest, we found that regular physical activity had no impact on the age-related elevation in circulating IL-18, eotaxin, GRO, IL-8, IP-10, PDGF-AA, or RANTES. Similarly, there was no impact of physical activity on the age-related reduction in VEGF, EGF, or IL-12 (p70). However, older exercisers had lower resting plasma fractalkine, IL-3, IL-6, and TNF-alpha compared to sedentary older adults. In contrast to our resting characterization, blood responses following acute exercise produced more striking difference between groups. Physically active younger and older subjects increased over 50% of the analyzed factors in their blood which resulted in both unique and overlapping exercise signatures. However, sedentary individuals, particularly the elderly, had few detectable changes in response to exercise. Overall, we show that long-term physical activity has a limited effect on age-associated changes in basal cytokines and chemokines in the healthy elderly, yet physically active individuals exhibit a broader induction of factors postexercise irrespective of age.
机译：衰老导致慢性、促炎症状态，可促进和加剧与年龄相关的疾病。相比之下，老年人的体育活动可以改善全身健康，预防疾病，减少炎症，但老年人的活动较少，因此很难将衰老的影响与久坐的生活方式区分开来。为了探究这种相互作用，我们分析了68名健康的年轻人和老年人在休息和运动后采集的外周血，这些人要么是运动有氧锻炼者，要么是长期久坐的人。受试者的外周血中有44种低丰度细胞因子、趋化因子和生长因子。休息时，我们发现规律的体育活动对循环中IL-18、eotaxin、GRO、IL-8、IP-10、PDGF-AA或RANTES的年龄相关升高没有影响。同样，体力活动对与年龄相关的VEGF、EGF或IL-12降低没有影响（第70页）。然而，与久坐的老年人相比，老年锻炼者的静息血浆fractalkine、IL-3、IL-6和TNF-α较低。与我们的静息表征相比，急性运动后的血液反应在各组之间产生了更显著的差异。年轻人和老年人的身体活动增加了血液中50%以上的分析因素，这导致了独特和重叠的运动特征。然而，久坐不动的人，尤其是老年人，对运动的反应几乎没有可察觉的变化。总的来说，我们表明，长期体育锻炼对健康老年人基础细胞因子和趋化因子的年龄相关变化的影响有限，但无论年龄大小，体育锻炼个体在运动后表现出更广泛的诱导因子。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号