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首页> 外文期刊>The journals of gerontology.Series A. Biological sciences and medical sciences >Effects of Heat Stress Treatment on Age-dependent Unfolded Protein Response in Different Types of Skeletal Muscle
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Effects of Heat Stress Treatment on Age-dependent Unfolded Protein Response in Different Types of Skeletal Muscle

机译：热应激治疗对不同类型骨骼肌中年龄依赖性展开蛋白应答的影响

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Mitochondrial and endoplasmic reticulum (ER) stress, and subsequently activated responses (mitochondrial/ER unfolded protein responses; UPRmt/UPRER), are involved in the pathogenesis of sarcopenia. To extend both basic and translational knowledge, we examined (i) whether age-induced mitochondrial and ER stress depend on skeletal muscle type in mice and (ii) whether heat stress treatment, a suggested strategy for sarcopenia, improves age-induced mitochondrial and ER stress. Aged (21-month-old) mice showed more severe mitochondrial stress and UPRmt than young (12-week-old) mice, based on increased oxidative stress, mitochondrial proteases, and mitochondrial E3 ubiquitin ligase. The aged mice also showed ER stress and UPRER, based on decreased ER enzymes and increased ER stress-related cell death. These changes were much more evident in soleus muscle than in gastrocnemius and plantaris muscles. After daily heat stress treatment (40 degrees C chamber for 30 minutes per day) for 4 weeks, mice showed remarkable improvements in age-related changes in soleus muscle. Heat stress had only minor effects in gastrocnemius and plantaris muscles. Based on these findings, age-associated mitochondrial stress, ER stress, and UPRmt/ER vary qualitatively with skeletal muscle type. Our results suggest a molecular basis for the beneficial effects of heat stress on muscle atrophy with age in soleus muscle.
机译：线粒体和内质网（ER）应激以及随后的激活反应（线粒体/ER未折叠蛋白反应；UPRmt/UPER）参与了肌肉减少症的发病机制。为了扩展基础知识和翻译知识，我们研究了（i）年龄诱导的线粒体和内质网应激是否依赖于小鼠骨骼肌的类型，以及（ii）热应激治疗（一种针对肌肉减少症的建议策略）是否能改善年龄诱导的线粒体和内质网应激。基于氧化应激、线粒体蛋白酶和线粒体E3泛素连接酶的增加，老年（21个月大）小鼠比年轻（12周大）小鼠表现出更严重的线粒体应激和UPRmt。老年小鼠也表现出内质网应激和内质网上调，这是基于内质网酶的降低和内质网应激相关细胞死亡的增加。比目鱼肌的这些变化比腓肠肌和跖肌明显得多。在每日热应激处理（40摄氏度，每天30分钟）4周后，小鼠比目鱼肌的年龄相关变化显著改善。热应激对腓肠肌和足底肌的影响较小。基于这些发现，与年龄相关的线粒体应激、内质网应激和UPRmt/ER在骨骼肌类型上存在质的差异。我们的结果为热应激对比目鱼肌随年龄增长的肌肉萎缩的有益影响提供了分子基础。

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