Macular Ganglion Cell-Inner Plexiform Layer as a Marker of Cognitive and Sensory Function in Midlife

Merten Natascha; Paulsen Adam J.; Pinto A. Alex; Chen Yanjun; Dillard Lauren K.; Fischer Mary E.; Huang Guan-Hua; Klein Barbara E. K.; Schubert Carla R.; Cruickshanks Karen J.

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Macular Ganglion Cell-Inner Plexiform Layer as a Marker of Cognitive and Sensory Function in Midlife

机译：黄斑神经节细胞内丛状层作为中期的认知和感官功能标志物

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Background: Neurodegenerative diseases are public health challenges in aging populations. Early identification of people at risk for neurodegeneration might improve targeted treatment. Noninvasive, inexpensive screening tools are lacking but are of great potential. Optical coherence tomography (OCT) measures the thickness of nerve cell layers in the retina, which is an anatomical extension of the brain and might be indicative of common underlying neurodegeneration. We aimed to determine the association of macular ganglion cell-inner plexiform layer (mGCIPL) thickness with cognitive and sensorineural function in midlife.

机译：背景：神经退行性疾病是老龄人口面临的公共卫生挑战。早期发现有神经退行性变风险的人可能会改善靶向治疗。目前缺乏无创、廉价的筛查工具，但潜力巨大。光学相干断层扫描（OCT）测量视网膜中神经细胞层的厚度，这是大脑的解剖学延伸，可能表明常见的潜在神经变性。我们的目的是确定中年时黄斑神经节细胞内丛状层（mGCIPL）厚度与认知和感觉神经功能的关系。

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来源
《The journals of gerontology.Series A. Biological sciences and medical sciences》 |2020年第9期|共7页
作者
Merten Natascha; Paulsen Adam J.; Pinto A. Alex; Chen Yanjun; Dillard Lauren K.; Fischer Mary E.; Huang Guan-Hua; Klein Barbara E. K.; Schubert Carla R.; Cruickshanks Karen J.;
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作者单位

Univ Wisconsin Sch Med &

Publ Hlth Dept Populat Hlth Sci WARF Off Bldg 610 Walnut St Madison;

Univ Wisconsin Sch Med &

Publ Hlth Dept Ophthalmol &

Visual Sci Madison WI 53726 USA;

Univ Wisconsin Sch Med &

Publ Hlth Dept Ophthalmol &

Visual Sci Madison WI 53726 USA;

Univ Wisconsin Sch Med &

Publ Hlth Dept Ophthalmol &

Visual Sci Madison WI 53726 USA;

Univ Wisconsin Sch Med &

Publ Hlth Dept Populat Hlth Sci WARF Off Bldg 610 Walnut St Madison;

Univ Wisconsin Sch Med &

Publ Hlth Dept Ophthalmol &

Visual Sci Madison WI 53726 USA;

Natl Chiao Tung Univ Inst Stat Hsinchu Taiwan;

Univ Wisconsin Sch Med &

Publ Hlth Dept Ophthalmol &

Visual Sci Madison WI 53726 USA;

Univ Wisconsin Sch Med &

Publ Hlth Dept Ophthalmol &

Visual Sci Madison WI 53726 USA;

Univ Wisconsin Sch Med &

Publ Hlth Dept Populat Hlth Sci WARF Off Bldg 610 Walnut St Madison;

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原文格式 PDF
正文语种 eng
中图分类老年病学;
关键词
Retinal thickness; Biomarker; Cognition; Vision; Senses;

机译：视网膜厚度;生物标志物;认知;愿景;感官;

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专利

1. Comment on “Correlation between macular ganglion cell-inner plexiform layer thickness and visual acuity after resolution of the macular edema secondary to central retinal vein occlusion” [J] . Dan Calugaru1, Mihai Calugaru1 国际眼科杂志：英文版 . 2019,第004期
2. Correlation between macular ganglion cell-inner plexiform layer thickness and visual acuity after resolution of the macular edema secondary to central retinal vein occlusion [J] . Hyun Ju Kim, Han Gyul Yoon, Seong Taeck Kim 国际眼科杂志：英文版 . 2018,第002期
3. Different damage patterns of retinal nerve fiber layer and ganglion cell-inner plexiform layer between early glaucoma and non-glaucomatous optic neuropathy [J] . Hui Xiao, Xing Liu, Ping Lian, 国际眼科杂志：英文版 . 2020,第006期
4. Retinal nerve fiber layer and ganglion cell-inner plexiform layer thickness in children with obesity [J] . Selim Demir1, Samet ozer2, Sait Alim1, 国际眼科杂志：英文版 . 2016,第003期
5. Comparisons of ganglion cell-inner plexiform layer loss patterns and its diagnostic performance between normal tension glaucoma and primary open angle glaucoma: a detailed, severity-based study [J] . Xiao-Yu Xu, Kun-Bei Lai, Hui Xiao, 国际眼科杂志：英文版 . 2020,第001期
6. Macular Ganglion Cell–Inner Plexiform Layer as a Marker of Cognitive and Sensory Function in Midlife [J] . Natascha Merten, Adam Paulsen, A Alex Pinto, Innovation in aging. . 2020,第Supplementa1期

机译：黄斑神经节细胞内丛状层作为中期的认知和感官功能的标志物
7. Evaluation of the Macular Ganglion Cell-Inner Plexiform Layer and the Circumpapillary Retinal Nerve Fiber Layer in Early to Severe Stages of Glaucoma: Correlation with Central Visual Function and Visual Field Indexes [J] . Pilar Bambo Maria, Guerri Noemi, Ferrandez Blanca, Ophthalmic Research: Journal for Research in Experimental and Clinical Ophthalmology . 2017,第4期

机译：黄金神经节细胞内丛状层及其在青光眼严重阶段的黄金神经节细胞内丛状层和环状视网膜神经纤维层的评价：与中心视野和视野指标的相关性
8. Comparative study of macular ganglion cell-inner plexiform layer and peripapillary retinal nerve fiber layer measurement: Structure-function analysis [J] . ShinH.-Y., ParkH.-Y.L., JungK.I., Investigative ophthalmology & visual science . 2013,第12期

机译：黄斑神经节细胞内丛状层和乳头周围视网膜神经纤维层测量的比较研究：结构功能分析
9. Improving cognitive functions of dyslexies using multi-sensory learning and EEG neurofeedback [C] . Günet Eroğlu, Serap Aydın, Müjdat Çetin, Signal Processing and Communications Applications Conference . 2018

机译：使用多感觉学习和EEG神经反馈改善阅读障碍的认知功能
10. Cognitive Function and Decline among Older Adults: The Roles of Sensory Loss and Psychosocial Factors [D] . Ge, Shaoqing. 2019

机译：老年人的认知功能与下降：感官损失和心理社会因素的作用
11. Macular Ganglion Cell–Inner Plexiform Layer as a Marker of Cognitive and Sensory Function in Midlife [O] . Natascha Merten, Adam Paulsen, A Alex Pinto, 2020

机译：黄斑神经节细胞内丛状层作为中期的认知和感官功能的标志物
12. Macular Ganglion Cell-Inner Plexiform Layer, Ganglion Cell Complex, and Outer Retinal Layer Thicknesses in a Large Cohort of Chinese Children [O] . Lu Cheng, Mingjin Wang, Junjie Deng, 2019

机译：黄斑神经节细胞内丛林层，神经节细胞复合物和外视网膜厚度在大群体中的中国儿童
13. The Effects of Sensory Deprivation on Sensory, Perceptual, Motor, Cognitive, and Physiological Functions [R] . Fisher, L., Richlin, M., Weinstein, S., 1967

机译：感觉剥夺对感觉，感知，运动，认知和生理功能的影响

Macular Ganglion Cell-Inner Plexiform Layer as a Marker of Cognitive and Sensory Function in Midlife

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