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首页> 外文期刊>Ophthalmic Research: Journal for Research in Experimental and Clinical Ophthalmology >Evaluation of the Macular Ganglion Cell-Inner Plexiform Layer and the Circumpapillary Retinal Nerve Fiber Layer in Early to Severe Stages of Glaucoma: Correlation with Central Visual Function and Visual Field Indexes
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Evaluation of the Macular Ganglion Cell-Inner Plexiform Layer and the Circumpapillary Retinal Nerve Fiber Layer in Early to Severe Stages of Glaucoma: Correlation with Central Visual Function and Visual Field Indexes

机译：黄金神经节细胞内丛状层及其在青光眼严重阶段的黄金神经节细胞内丛状层和环状视网膜神经纤维层的评价：与中心视野和视野指标的相关性

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Objectives: To compare the circumpapillary retinal nerve fiber layer (cpRNFL) and the macular ganglion cell-inner plexiform layer (GCIPL) in glaucoma patients at different disease stages and to evaluate correlations between optical coherence tomography (OCT) parameters with central visual function and visual field (VF) indexes. Patients and Methods: One hundred forty patients were included in this prospective cross-sectional study. Subjects diagnosed with chronic open-angle glaucoma and 20/40 or better vision were recruited and classified as having early, moderate, or severe VF defects based on Hodapp-Parrish-Anderson criteria. cpRNFL and macular GCIPL were measured using Cirrus high-definition OCT. Central retinal sensitivity and visual acuity were recorded. Results: All OCT measurements differed significantly between patients with early and severe VF defects (p < 0.001). Correlations between central vision and VF indexes with OCT measurements were moderate but significant; better-correlated OCT parameters were the inferior cpRNFL quadrant, average cpRNFL thickness, inferior and inferior temporal GCIPL sectors, and minimum GCIPL thickness (r = 0.63-0.71, p < 0.001). Visual acuity was not correlated with either circumpapillary or macular OCT measurements. Conclusions: Inner macular parameters performed as well as cpRNFL in patients with different stages of glaucoma. Inferior macular GCIPL sectors, minimum GCIPL thickness, and the inferior cpRNFL quadrant best differentiate disease severity and correlate with central visual function and VF indexes. (C) 2017 S. Karger AG, Basel
机译：目标：将环状视网膜神经纤维层（CPRNFL）和黄斑神经节细胞内丛状层（GCIPL）与不同疾病阶段进行比较，并在中央视觉功能和视觉中评估光学相干断层扫描（OCT）参数之间的相关性字段（VF）索引。患者和方法：在这项前瞻性横截面研究中纳入一百四十名患者。招募诊断患有慢性开口角胶质瘤的受试者和20/40或更好的视力，并归类为基于Hodapp-Parrish-Anderson标准的早期，中等或严重的VF缺陷。使用Cirrus高清OCT测量CPRNFL和黄斑GCIPL。记录中央视网膜敏感性和视力。结果：患有早期和严重损伤的患者之间的所有OCT测量值显着不同（P <0.001）。中央视觉和VF指数与OCT测量的相关性相适中但重要;更相关的OCT参数是劣质CPRNFL象限，平均CPRNFL厚度，劣质和较差的时间GCIPL扇区，以及最小的GCIPL厚度（R = 0.63-0.71，P <0.001）。视力与环状或黄斑OCT测量无关。结论：在葡萄糖多阶段的患者中表演和CPRNFL的内部黄斑参数。劣质黄斑的Gcipl扇区，最小Gcipl厚度，以及劣质CPRNFL象限最佳区分疾病严重程度，与中央视觉功能和VF指标相关。 （c）2017年S. Karger AG，巴塞尔

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