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首页> 外文期刊>The journals of gerontology.Series A. Biological sciences and medical sciences >Differential Responses of White Adipose Tissue and Brown Adipose Tissue to Calorie Restriction During Aging
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Differential Responses of White Adipose Tissue and Brown Adipose Tissue to Calorie Restriction During Aging

机译：白色脂肪组织和棕色脂肪组织对老化差异抗脂肪组织的差分反应

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摘要

Age-related adipose tissue dysfunction is potentially important in the development of insulin resistance and metabolic disorder. Caloric restriction (CR) is a robust intervention to reduce adiposity, improve metabolic health, and extend healthy life span. Both white adipose tissue (WAT) and brown adipose tissue (BAT) are involved in energy homeostasis. CR triggers the beiging of WAT in young mice; however, the effects of CR on beiging of WAT and function of BAT during aging are unclear. This study aimed to investigate how age and CR impact the beiging of WAT, the function of BAT, and metabolic health in mice. C57BL/6 mice were fed CR diet (40% less than the ad libitum [AL] diet) for 3 months initiated in young (3 months), middle-aged (12 months), and old (19 months) stage. We found age-related changes in different types of adipose tissue, including adipocyte enlargement, declined beiging of WAT, and declined thermogenic and beta-oxidational function of BAT. Moreover, CR attenuated age-associated adipocyte enlargement and prevented the age-related decline in beiging potential of WAT. These protective effects on the beiging potential were significant in inguinal WAT at all three ages, which were significant in epididymal WAT at young and old age. In contrast, thermogenic and beta-oxidational function of BAT further declined after CR in the young age group. In conclusion, our findings reveal the contribution of WAT beiging decline to age-related metabolic disorder and suggest nutritional intervention, specifically targeting WAT beiging, as an effective approach to metabolic health during aging.
机译：与年龄相关的脂肪组织功能障碍在胰岛素抵抗和代谢紊乱的发展中可能很重要。热量限制（CR）是减少肥胖、改善代谢健康和延长健康寿命的有力干预措施。白色脂肪组织（WAT）和棕色脂肪组织（BAT）都参与能量平衡。CR引起幼鼠WAT变黄；然而，铬对WAT老化和BAT功能的影响尚不清楚。本研究旨在研究年龄和CR对小鼠WAT的老化、BAT的功能和代谢健康的影响。C57BL/6小鼠在幼年期（3个月）、中年期（12个月）和老年期（19个月）开始喂食CR饮食（比随意[AL]饮食少40%）。我们在不同类型的脂肪组织中发现了与年龄相关的变化，包括脂肪细胞增大、WAT变薄、BAT的产热和β-氧化功能下降。此外，CR可减轻与年龄相关的脂肪细胞增大，并防止WAT的老化潜能下降。在所有三个年龄段的腹股沟WAT中，这些对beiging电位的保护作用都是显著的，这在年轻和老年的附睾WAT中是显著的。相比之下，在年轻组中，CR后BAT的产热和β-氧化功能进一步下降。总之，我们的研究结果揭示了WAT beiging下降对年龄相关代谢紊乱的贡献，并提出了营养干预，特别是针对WAT beiging的营养干预，作为老年代谢健康的有效途径。

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    Sheng Yunlu; Xia Fan; Chen Lei; Lv Yifan; Lv Shan; Yu Jing; Liu Juan; Ding Guoxian;

  • 作者单位

    Nanjing Med Univ Affiliated Hosp 1 Div Geriatr Endocrinol 300 Guangzhou Rd Nanjing 210029;

    Nanjing Med Univ Affiliated Hosp 1 Div Geriatr Endocrinol 300 Guangzhou Rd Nanjing 210029;

    Nanjing Med Univ Affiliated Hosp 1 Div Geriatr Resp Nanjing Peoples R China;

    Nanjing Med Univ Affiliated Hosp 1 Div Geriatr Endocrinol 300 Guangzhou Rd Nanjing 210029;

    Nanjing Med Univ Affiliated Hosp 1 Div Geriatr Endocrinol 300 Guangzhou Rd Nanjing 210029;

    Nanjing Med Univ Affiliated Hosp 1 Div Geriatr Endocrinol 300 Guangzhou Rd Nanjing 210029;

    Nanjing Med Univ Affiliated Hosp 1 Div Geriatr Endocrinol 300 Guangzhou Rd Nanjing 210029;

    Nanjing Med Univ Affiliated Hosp 1 Div Geriatr Endocrinol 300 Guangzhou Rd Nanjing 210029;

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  • 正文语种 eng
  • 中图分类 老年病学;
  • 关键词

    Calorie restriction; iWAT; eWAT; BAT; Beiging;

    机译：卡路里限制;他;坏;坏;烘烤;

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