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首页> 外文期刊>The journals of gerontology.Series A. Biological sciences and medical sciences >A Young Blood Environment Decreases Aging of Senile Mice Kidneys
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A Young Blood Environment Decreases Aging of Senile Mice Kidneys

机译：年轻的血液环境降低了老年小鼠肾脏的老化

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Whether changes in internal body environment affect kidney aging remains unclear. Specifically, it is unknown whether transplanted kidneys from older donors recover from tissue damage after placement in younger recipients. In this study, a parabiosis animal model was established to investigate the effects of a young internal body environment on aged kidneys. The animals were divided into six groups: young (Ycon) and old control (Ocon) groups, isochronic youth–youth group (Y-IP), elderly–elderly group (O-IP), and heterochronic youth (Y-HP) and elderly (O-HP) groups. After parabiosis, tubule and interstitial tissue scores in the O-HP group were significantly lower than in the Ocon and O-IP groups. The expression of aging-related protein p16 and SA-β-gal in the O-HP group was significantly reduced compared with the Ocon and O-IP groups. Autophagy factors Atg5 and LC3BII were significantly upregulated, whereas the expression of the autophagic degradation marker (P62) was significantly downregulated in the O-HP group compared with the Ocon and O-IP groups. With the same comparison, the positive cells of TUNEL staining and the expression of IL-6 and IL-1β were significantly reduced, whereas the total/cleaved caspase-3 and total/pNF-κB were significantly increased in the O-HP group. The results demonstrated that a young blood environment significantly reduces kidney aging. These findings provide new evidence supporting an increase in the upper age limit for human kidney transplantation donors.
机译：体内环境的变化是否会影响肾脏衰老尚不清楚。具体而言，目前尚不清楚老年捐赠者的移植肾在植入年轻受体后是否能从组织损伤中恢复。在本研究中，建立了一个抛物体动物模型，以研究年轻的体内环境对老年肾脏的影响。这些动物被分为六组：青年组（Ycon）和老年对照组（Ocon）、等时青年-青年组（Y-IP）、老年-老年组（O-IP）、异慢性青年组（Y-HP）和老年组（O-HP）。抛物体形成后，O-HP组的小管和间质组织评分显著低于Ocon组和O-IP组。与Ocon和O-IP组相比，O-HP组衰老相关蛋白p16和SA-β-gal的表达显著降低。与Ocon和O-IP组相比，O-HP组的自噬因子Atg5和LC3BII显著上调，而自噬降解标记物（P62）的表达显著下调。同样的比较，在O-HP组中，TUNEL染色阳性细胞、IL-6和IL-1β的表达显著减少，而总/裂解的caspase-3和总/pNF-κB显著增加。结果表明，年轻的血液环境可以显著减少肾脏衰老。这些发现为提高人类肾移植供体的年龄上限提供了新的证据。

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