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首页> 外文期刊>Tierarztliche Praxis, Ausgabe K. Kleintiere >Disseminated protothecosis with ulcerative granulomatous colitis in a Rhodesian Ridgeback from Germany
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Disseminated protothecosis with ulcerative granulomatous colitis in a Rhodesian Ridgeback from Germany

机译：德国罗得岛Ridgeback中溃疡性肉芽炎的发育原子病

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A 10-month-old male Rhodesian Ridgeback was presented to the Clinic of Small Animal Medicine, LMU, Germany, with a 6-month history of chronic diarrhea and hematochezia. The dog lived in Germany and had never traveled abroad. Complete blood count and serum biochemistry performed by the referring veterinarian revealed neutrophilia, hyperkalemia, and hyponatremia, with a basal cortisol of 4.3 mu g/dl, which excluded hypoadrenocorticism. Since antibiotic treatment had not resulted in any improvement, a 2 week course of prednisolone administration had been initiated, leading to a marked deterioration of intestinal signs and a significant weight loss of 6 kg. At the time of referral, the patient was markedly emaciated, dehydrated, hypovolemic and had a rectal temperature of 39.6 degrees C. Abdominal ultrasound showed a thickened and irregular colonic wall. On colonoscopy, an irregular colonic mucosa with ulcerations was observed. Histopathologic examination revealed an ulcerative granulomatous colitis, and on Periodic acid-Schiff reaction (PAS) numerous organisms consistent with Prototheca spp. were identified. Prototheca zopfii infection was confirmed by culture and MALDI-TOF MS. In order to test for an underlying immunodeficiency, immunoglobulin levels in serum were determined. IgM was decreased, while IgG and IgA levels were within the reference interval. Due to deterioration of general condition, grave prognosis and costs of a treatment trial, the patient was euthanized one week later, and necropsy was performed. Prototheca spp. were detected on histopathologic examination in the lymphnodes, however not in the eyes or the central nervous system. Protothecosis should be-considered an differential diagnosis in dogs with chronic diarrhea and ulcerative granulomatous colitis even in dogs living in Germany. Histopathologic examination of colonic biopsies with special stains such as PAS is recommended in every dog with signs of chronic large bowel disease in order to avoid missing this rare infectious disease.
机译：一只10个月大的雄性罗得西亚脊背犬被送到德国LMU小动物医学诊所，有6个月的慢性腹泻和便血病史。这条狗生活在德国，从未出过国。转诊兽医进行的全血计数和血清生化检查显示，中性粒细胞增多、高钾血症和低钠血症，基础皮质醇为4.3μg/dl，排除了肾上腺皮质功能减退症。由于抗生素治疗没有导致任何改善，因此开始了为期2周的泼尼松龙给药疗程，导致肠道症状明显恶化，体重显著减轻6公斤。转诊时，患者明显消瘦、脱水、低血容量，直肠温度为39.6摄氏度。腹部超声显示结肠壁增厚且不规则。在结肠镜检查中，观察到不规则的结肠粘膜溃疡。病理组织学检查发现溃疡性肉芽肿性结肠炎，在高碘酸希夫反应（PAS）中发现了许多与原膜菌属一致的微生物。通过培养和MALDI-TOF MS确认zopfii原膜菌感染。为了检测潜在的免疫缺陷，测定血清中的免疫球蛋白水平。IgM降低，而IgG和IgA水平在参考区间内。由于病情恶化、预后严重以及治疗试验的费用，患者在一周后被安乐死，并进行了尸检。在淋巴结的组织病理学检查中检测到原膜菌，但在眼睛或中枢神经系统中未检测到。在患有慢性腹泻和溃疡性肉芽肿性结肠炎的狗中，即使是生活在德国的狗，也应将原膜病视为一种鉴别诊断。建议对每只有慢性大肠疾病症状的狗进行结肠活检组织病理学检查，以避免遗漏这种罕见的传染病。

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