Baicalin benefits the anti-HBV therapy via inhibiting HBV viral RNAs

Huang Hai; Zhou Wei; Zhu Haiyan; Zhou Pei; Shi Xunlong

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Baicalin benefits the anti-HBV therapy via inhibiting HBV viral RNAs

机译：黄芩苷通过抑制HBV病毒RNA有益于抗HBV治疗

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Background: Although current antiviral treatments (nucleoside analogs, NAs) for chronic hepatitis B virus (HBV) infection are effective in suppressing HBV-DNA replication, their clinical outcomes can be compromised by the increasing drug resistance and the inefficiency in promoting HBsAg/HBeAg seroconversion.

机译：背景：尽管目前针对慢性乙型肝炎病毒（HBV）感染的抗病毒治疗（核苷类似物，NAs）在抑制HBV-DNA复制方面有效，但其临床结果可能会因耐药性增加和促进HBsAg/HBeAg血清转化效率低下而受损。

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来源
《Toxicology and Applied Pharmacology》 |2017年第2017期|共8页
作者
Huang Hai; Zhou Wei; Zhu Haiyan; Zhou Pei; Shi Xunlong;
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作者单位

Fudan Univ Sch Pharm Dept Microbiol &

Biopharm 826 Zhangheng Rd Shanghai 201203 Peoples R China;

Fudan Univ Dept Chem 220 Han Dan Rd Shanghai 200433 Peoples R China;

Fudan Univ Sch Pharm Dept Microbiol &

Biopharm 826 Zhangheng Rd Shanghai 201203 Peoples R China;

Fudan Univ Sch Pharm Dept Microbiol &

Biopharm 826 Zhangheng Rd Shanghai 201203 Peoples R China;

Fudan Univ Sch Pharm Dept Microbiol &

Biopharm 826 Zhangheng Rd Shanghai 201203 Peoples R China;

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原文格式 PDF
正文语种 eng
中图分类毒物学（毒理学）;
关键词
Baicalin; Anti-HBV; Nucleoside analog; HBV RNAs; Hepatocyte nuclear factors;

机译：黄芩苷;抗HBV;核苷类似物;HBV RNA;肝细胞核因子;

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专利

1. HBV X-gene: A new serum marker for anti-HBV therapy monitoring [J] . 中国人民解放军军医大学学报（英文版） . 2007,第006期
2. Monitoring lamivudine therapy in HBV-infected patients by the quantity and structures of circulating viral nucleic acids [J] . ZHANG Wei(张伟), Hans Jorg Hacker, Maria Mildenberger, 中国人民解放军军医大学学报（英文版） . 2003,第003期
3. Baicalin benefits the anti-HBV therapy via inhibiting HBV viral RNAs [J] . Huang Hai, Zhou Wei, Zhu Haiyan, Toxicology and Applied Pharmacology . 2017,第期

机译：黄芩苷通过抑制HBV病毒RNA有益于抗HBV治疗
4. Enhanced antiviral benefit of combination therapy with anti-HBV and anti-PD1 gRNA/cas9 produces a synergistic antiviral effect in HBV infection [J] . Zhen Shuai, Qiang Rong, Lu Jiaojiao, Molecular Immunology . 2021,第1期

机译：增强抗HBV和抗PD1 GRNA / CAS组合治疗的抗病毒益处在HBV感染中产生协同抗病毒作用
5. Does anti-HBV therapy benefit the prognosis of HBV- related hepatocellular carcinoma following hepatectomy? [J] . YuL.-H., LiN., ShiJ., Annals of surgical oncology . 2014,第3期

机译：抗HBV疗法对肝切除术后HBV相关性肝细胞癌的预后有帮助吗？
6. Dynamics analysis of an amended HBV infection model with a simulation for anti-HBV infection therapy [C] . Chen Xiao, Sun Kaiyun, Qiu Jianlong, Chinese Control Conference . 2014

机译：经抗HBV感染治疗模拟的修正HBV感染模型的动态分析
7. The anti-HBV studies of a novel series of acyclic pyrimidine nucleoside analogs. [D] . Semaine, Wassila Wafaa. 2005

机译：一系列新的无环嘧啶核苷类似物的抗HBV研究。
8. Inhibition of Post-Transcriptional RNA Processing by CDK Inhibitors and Its Implication in Anti-Viral Therapy [O] . Jitka Holcakova, Petr Muller, Peter Tomasec, 2010

机译：CDK抑制剂对转录后RNA加工的抑制作用及其在抗病毒治疗中的意义
9. Differential reductions in viral antigens expressed from cccDNAVS integrated DNA in treatment naïve HBeAg positive and negative patients with chronic HBV after RNA interference therapy with ARC-520 [O] . Locarnini SA, Lau JYN, Lai CL, 2016

机译：在aRC-520 RNa干扰治疗后，用于治疗初治HBeag阳性和阴性慢性HBV患者的cccDNaVs整合DNa表达的病毒抗原差异减少
10. Detection of Viral RNA From Paraffin-Embedded Tissues After Prolonged Formalin Fixation [R] . McKinney, M. D., Moon, S. J., Kulesh, D. A., 2009

机译：长时间福尔马林固定后石蜡包埋组织中病毒RNa的检测

Baicalin benefits the anti-HBV therapy via inhibiting HBV viral RNAs

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