...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Toxicology and Applied Pharmacology >Co-administration of Luteolin mitigated toxicity in rats' lungs associated with doxorubicin treatment
【24h】

Co-administration of Luteolin mitigated toxicity in rats' lungs associated with doxorubicin treatment

机译：大鼠肺与多柔枯蛋白治疗相关的叶黄素减去毒性的共同施用

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Doxorubicin (DOX), is a drug against lung malignancies with undesirable side effect including oxidative, inflammatory and apoptotic effects. Luteolin (LUT), present in fruits and vegetables is pharmacologically active against oxido-inflammatory and apoptotic responses. The present study examined the effect of LUT on DOX-induced lungs and blood dysfunction in Wistars rat (sex: male; 10 weeks old, 160 +/- 5 g). Randomly grouped (n = 10) rats were treated as follows: control, LUT alone (100 mg/kg; per os), DOX (2 mg/kg; i. p), and co-treated rats with LUT (50 or 100 mg/kg) and DOX for two consecutive weeks. DOX alone adversely altered the final body and relative organ weights, red and white blood cell and platelet counts. DOX significantly (p > 0.05) reduced lungs antioxidant capacity, and anti-inflammatory cytokines; increased biomarkers of oxidative stress, caspase-3 activity, and pro-inflammatory cytokine. Morphological damages accompanied these biochemical alterations in the lung of experimental rats. Co-treatment with LUT, dose-dependently reversed DOX-mediated changes in rats' survival, toxic responses, and diminished oxidative stress in rat's lungs. Furthermore, co-treatment with LUT resulted in the reduction of pro-inflammatory cytokines and apoptotic biomarkers, increased red and white blood cell, platelet counts and abated pathological injuries in rat lungs treated with DOX alone. In essence, our findings indicate that LUT dose-dependently mitigated DOX-induced toxicities in the lungs and haematopoietic systems. Supplementation of patients on DOX-chemotherapy with phytochemicals exhibiting antioxidant activities, specifically LUT, could circumvent the onset of unintended toxic responses in the lungs and haematopoietic system exposed to DOX.
机译：阿霉素（DOX）是一种治疗肺部恶性肿瘤的药物，具有不良副作用，包括氧化、炎症和凋亡作用。木犀草素（LUT）存在于水果和蔬菜中，对氧化炎症和凋亡反应具有药理活性。本研究在Wistars大鼠（性别：雄性；10周龄，160+/-5g）中检测了LUT对DOX诱导的肺和血液功能障碍的影响。随机分组（n=10）的大鼠按如下方式进行治疗：对照组、单独使用LUT（100 mg/kg；每os）、DOX（2 mg/kg；i.p）和联合使用LUT（50或100 mg/kg）和DOX的大鼠，连续两周。单用DOX会对最终体重、相对器官重量、红细胞、白细胞和血小板计数产生不利影响。DOX显著（p>0.05）降低肺的抗氧化能力和抗炎细胞因子；氧化应激、caspase-3活性和促炎细胞因子的生物标志物增加。在实验大鼠的肺中，这些生化变化伴随着形态学损伤。与LUT联合治疗后，剂量依赖性逆转了DOX介导的大鼠存活、毒性反应和大鼠肺氧化应激的变化。此外，与LUT联合治疗导致促炎细胞因子和凋亡生物标志物减少，红细胞和白细胞、血小板计数增加，并减轻了单独使用DOX治疗的大鼠肺的病理损伤。本质上，我们的研究结果表明，LUT剂量依赖性地减轻了DOX诱导的肺部和造血系统毒性。对接受DOX化疗的患者补充具有抗氧化活性的植物化学物质，特别是LUT，可以避免暴露于DOX的肺部和造血系统出现意外毒性反应。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号