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Surface Area to Volume Ratio: A Natural Variable for Bacterial Morphogenesis

机译:表面积为体积比:细菌形态发生的天然变量

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摘要

An immediately observable feature of bacteria is that cell size and shape are remarkably constant and characteristic for a given species in a particular condition, but vary quantitatively with physiological parameters such as growth rate, indicating both genetic and environmental regulation. However, despite decades of research, the molecular mechanisms underlying bacterial morphogenesis have remained incompletely characterized. We recently demonstrated that a wide range of bacterial species exhibit a robust surface area to volume ratio (SA/V) homeostasis. Because cell size, shape, and SA/V are mathematically interconnected, if SA/V is indeed the natural variable that cells actively monitor, this finding has critical implications for our understanding of bacterial morphogenesis, placing fundamental constraints on the sizes and shapes that cells can adopt. In this Opinion article we discuss the broad implications that this novel perspective has for the field of bacterial growth and morphogenesis.
机译:细菌的一个可立即观察到的特征是,在特定条件下,特定物种的细胞大小和形状非常恒定,具有特征性,但随着生长速率等生理参数的变化而在数量上有所不同,这表明了遗传和环境调节。然而,尽管进行了几十年的研究,细菌形态发生的分子机制仍不完全清楚。我们最近证明,许多细菌种类表现出强大的表面积体积比(SA/V)稳态。由于细胞大小、形状和SA/V在数学上是相互关联的,如果SA/V确实是细胞主动监测的自然变量,这一发现对我们理解细菌形态发生具有关键意义,对细胞可以采用的大小和形状设置了基本限制。在这篇观点文章中,我们讨论了这一新视角对细菌生长和形态发生领域的广泛影响。

著录项

  • 来源
    《Trends in Microbiology》 |2018年第10期|共18页
  • 作者单位

    Department of Molecular and Cell Biology University of California Berkeley;

    Department of Biochemistry Department of Microbiology &

    Immunology Howard Hughes Medical Institute Stanford University School of Medicine;

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  • 原文格式 PDF
  • 正文语种 other
  • 中图分类 微生物学;
  • 关键词

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