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首页> 外文期刊>Trends in Microbiology >Surface Area to Volume Ratio: A Natural Variable for Bacterial Morphogenesis
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Surface Area to Volume Ratio: A Natural Variable for Bacterial Morphogenesis

机译：表面积为体积比：细菌形态发生的天然变量

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摘要

An immediately observable feature of bacteria is that cell size and shape are remarkably constant and characteristic for a given species in a particular condition, but vary quantitatively with physiological parameters such as growth rate, indicating both genetic and environmental regulation. However, despite decades of research, the molecular mechanisms underlying bacterial morphogenesis have remained incompletely characterized. We recently demonstrated that a wide range of bacterial species exhibit a robust surface area to volume ratio (SA/V) homeostasis. Because cell size, shape, and SA/V are mathematically interconnected, if SA/V is indeed the natural variable that cells actively monitor, this finding has critical implications for our understanding of bacterial morphogenesis, placing fundamental constraints on the sizes and shapes that cells can adopt. In this Opinion article we discuss the broad implications that this novel perspective has for the field of bacterial growth and morphogenesis.
机译：细菌的立即可观察特征是细胞尺寸和形状对于特定条件的给定物质具有显着恒定和特征，但定量地与生理学参数（例如生长速率）相差，表明遗传和环境调节。然而，尽管研究了几十年的研究，但细菌形态发生的分子机制仍然存在不完全的特征。我们最近证明，广泛的细菌物种表现出稳健的表面积（SA / V）稳态。由于小区尺寸，形状和SA / V在数学上互联，如果SA / V确实是细胞主动监测的天然变量，则该发现对我们对细菌形态发生的理解具有重要影响，将基本限制对细胞的尺寸和形状放置在尺寸和形状的情况下可以采纳。在这个意见中，我们讨论了这种新颖的视角对细菌生长和形态发生领域的广泛影响。

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  • 来源
    《Trends in Microbiology》 |2018年第10期|共18页
  • 作者

    Leigh K. Harris; Julie A. Theriot;

  • 作者单位

    Department of Molecular and Cell Biology University of California Berkeley;

    Department of Biochemistry Department of Microbiology &

    Immunology Howard Hughes Medical Institute Stanford University School of Medicine;

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  • 中图分类 微生物学;
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