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首页> 外文期刊>Tropical Animal Health and Production >Concurrent vaccination of goats with foot and mouth disease (FMD) and peste des petits ruminants (PPR) booster vaccines
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Concurrent vaccination of goats with foot and mouth disease (FMD) and peste des petits ruminants (PPR) booster vaccines

机译：山羊与脚口疾病（FMD）和Peste des Petits反刍动物（PPR）增强疫苗的同时接种疫苗

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Foot and mouth disease (FMD) remains subclinical and self-limiting in small ruminants, but risk of spread of infection to susceptible cohorts is of great epidemiological significance; therefore, small ruminants must be included in vaccination campaigns in FMD endemic regions. Three groups of goats already immunized against peste des petits ruminants (PPR) were vaccinated with FMD and PPR vaccines alone or concurrently. The specific antibody response against three FMD virus strains and PPR virus were evaluated by competitive enzyme-linked immunosorbent assay (cELISA). Goats concurrently vaccinated with PPR + FMD vaccines had significantly (p & 0.05) higher antibody titers to two serotypes of FMD virus at 28, 45, and 60 days post-immunization compared to goats vaccinated with FMD vaccine alone, while goats vaccinated with PPR vaccines alone or PPR + FMD vaccines concurrently showed similar antibody kinetics against PPR virus up till 60 days post-vaccination. Overall, antibody kinetic curves for all three tested strains of FMD virus and PPR virus were similar in vaccinated groups during the course of experiment.
机译：口蹄疫（FMD）在小型反刍动物中仍处于亚临床和自我限制状态，但感染传播到易感群体的风险具有重大流行病学意义；因此，口蹄疫流行地区的疫苗接种活动必须包括小型反刍动物。已接种小反刍动物鼠疫（PPR）疫苗的三组山羊单独或同时接种FMD和PPR疫苗。用竞争性酶联免疫吸附试验（cELISA）评价了三株FMD病毒和PPR病毒的特异性抗体反应。与单独接种FMD疫苗的山羊相比，同时接种PPR+FMD疫苗的山羊在免疫后28、45和60天对两种血清型FMD病毒的抗体滴度显著（p；0.05）更高，而单独接种PPR疫苗或同时接种PPR+FMD疫苗的山羊在接种后60天内对PPR病毒表现出相似的抗体动力学。总的来说，在实验过程中，接种疫苗组的所有三种受试FMD病毒株和PPR病毒株的抗体动力学曲线相似。

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