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首页> 外文期刊>Annals of Clinical and Laboratory Science: Official Journal of the Association of Clinical Scientists >Thyroid-like Follicular Carcinoma of the Kidney and Papillary Renal Cell Carcinoma with Thyroid-like Feature: Comparison of Two Cases and Literature Review
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Thyroid-like Follicular Carcinoma of the Kidney and Papillary Renal Cell Carcinoma with Thyroid-like Feature: Comparison of Two Cases and Literature Review

机译：肾脏甲状腺样滤泡癌和甲状腺样特征的乳头状肾细胞癌：两例比较及文献复习

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摘要

Thyroid-like follicular carcinoma of the kidney (TLFCK) is a provisional new entity of renal cell carcinoma (RCC). We herein reported and compared one TLFCK case and one PRCC case with thyroid-like feature. The former entirely consisted of thyroid-like follicular architecture and the tumor cells were diffusely positive for PAX-8, but negative for CK7, AMACR, and CD10. By contrast, both papillary architecture (similar to 60%) and thyroid-like follicular architecture (similar to 40%) were identified in the latter. Tumor cells in both histological components exhibited diffusely positive staining for PAX-8, CK7, AMACR, but negative for CD10. FISH analysis showed no aberration in TLFCK case but trisomy of chromosome 17 in PRCC case. Along with a brief literature review, we presented that recognition of TLFCK is important to distinguish it from other conditions that show thyroid-like features. Additionally, a diagnosis of TLFCK should be cautiously made when papillary component is present in the tumor.
机译：肾样甲状腺滤泡癌（TLFCK）是肾细胞癌（RCC）的临时新实体。我们在此报告并比较了1例TLFCK病例和1例具有甲状腺样特征的PRCC病例。前者完全由甲状腺样卵泡结构组成，肿瘤细胞对PAX-8呈弥漫阳性，而对CK7，AMACR和CD10呈阴性。相比之下，在后者中，乳头状结构（约占60％）和甲状腺样滤泡结构（约占40％）均被发现。两种组织学成分中的肿瘤细胞均对PAX-8，CK7，AMACR呈弥漫阳性染色，而对CD10呈阴性染色。 FISH分析显示TLFCK病例无畸变，PRCC病例17号染色​​体三体性。连同简短的文献综述，我们提出了对TLFCK的识别对于将其与其他表现出甲状腺样特征的疾病区分开很重要。另外，当肿瘤中存在乳头状成分时，应谨慎诊断TLFCK。

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