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首页> 外文期刊>Annals of oncology: official journal of the European Society for Medical Oncology >Brachytherapy after external beam radiotherapy and limited surgery preserves bladders for patients with solitary pT1-pT3 bladder tumors
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Brachytherapy after external beam radiotherapy and limited surgery preserves bladders for patients with solitary pT1-pT3 bladder tumors

机译：外照射放疗和有限的手术后的近距离放射治疗可保留孤立性pT1-pT3膀胱肿瘤患者的膀胱

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Background: Several French, Belgian and Dutch radiation oncologists have reported good results with the combination of limited surgery after external beam radiotherapy (EBRT) followed by brachytherapy in early-stage muscle-invasive bladder cancer. Patients and Methods: Data from 12 of 13 departments which are using this approach have been collected retrospectively, in a multicenter database, resulting in 1040 patients: 811 males and 229 females with a median age of 66 years, range 28-92 years. Results were analyzed according to tumor stage and diameter, histology grade, age and brachytherapy technique, continuous low-dose rate (CLDR) and pulsed dose rate (PDR). Results: At 1, 3 and 5 years, the local recurrence-free probability was 91%, 80% and 75%, metastasis-free probability was 91%, 80% and 74%, disease-free probability was 85%, 68% and 61% and overall survival probability was 91%, 74% and 62%, respectively. The differences in the outcome between the contributing departments were small. After multivariate analysis, the only factor influencing the local control rate was the brachytherapy technique. Toxicity consisted mainly of 24 fistula, 144 ulcersecroses and 93 other types. Conclusions: EBRT followed by brachytherapy, combined with limited surgery, offers excellent results in terms of bladder sparing for selected groups of patients suffering from bladder cancer.
机译：背景：几位法国，比利时和荷兰的放射肿瘤学家报告说，在早期的肌肉浸润性膀胱癌中，采用外束放疗（EBRT）后进行有限的手术，然后进行近距离放射治疗，相结合的效果很好。患者和方法：使用多中心数据库回顾性收集了使用这种方法的13个部门中的12个部门的数据，共收集了1040例患者：男811例，女229例，中位年龄66岁，范围28-92岁。根据肿瘤分期和直径，组织学等级，年龄和近距离放射治疗技术，连续低剂量率（CLDR）和脉冲剂量率（PDR）对结果进行分析。结果：在第1、3和5年，局部无复发的可能性分别为91％，80％和75％，无转移的可能性为91％，80％和74％，无疾病的可能性分别为85％，68％分别为61％和74％，而总生存率分别为74％和62％。贡献部门之间的结果差异很小。经过多变量分析，影响局部控制率的唯一因素是近距离放射治疗技术。毒性主要由24瘘，144溃疡/坏死和93其他类型组成。结论：EBRT加上近距离放射疗法，再加上有限的手术，在选定的膀胱癌患者群体中，在保留膀胱方面提供了出色的结果。

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