...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Hepatology research: the official journal of the Japan Society of Hepatology >Wisteria floribunda Wisteria floribunda Wisteria floribunda agglutinin‐positive human Mac‐2‐binding protein as a predictive marker of liver fibrosis in human immunodeficiency virus/hepatitis C virus coinfected patients
【24h】

Wisteria floribunda Wisteria floribunda Wisteria floribunda agglutinin‐positive human Mac‐2‐binding protein as a predictive marker of liver fibrosis in human immunodeficiency virus/hepatitis C virus coinfected patients

机译：Wisteria Floribunda Wisteria Floribunda Wisteria佛罗里达州氨苄青素阳性人类Mac-2结合蛋白作为人类免疫缺陷病毒/丙型肝炎病毒的肝纤维化中的预测标志物

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Aim In human immunodeficiency virus (HIV) and hepatitis?C virus (HCV) coinfected patients, the progression of liver failure is reported to be more aggressive than that in HCV mono‐infected patients. Wisteria floribunda agglutinin‐positive human Mac‐2‐binding protein (WFA + ‐M2BP) is well recognized as a liver fibrosis glycobiomarker with a unique fibrosis‐related glycoalteration. We analyzed HIV/HCV coinfected patients’ M2BP levels as a possible marker for predicting liver fibrosis. Methods M2BP was measured in 31 HIV/HCV coinfected patients, and we analyzed the correlation between WFA + ‐M2BP and several markers of fibrosis, liver function, and tumor markers. We compared the WFA + ‐M2BP levels in HIV/HCV coinfected patients with those of HCV mono‐infected patients by performing a propensity score matching analysis. Results In the HIV/HCV coinfected patients, the serum level of WFA + ‐M2BP was well correlated with the markers type?IV collagen, hyaluronic acid, and alpha‐fetoprotein, but not protein induced by vitamin K absence‐II. In the propensity score matching with HCV mono‐infected patients, the WFA + ‐M2BP levels were significantly higher in the HIV/HCV coinfected patients compared with the levels in the HCV mono‐infected patients. Conclusion In conclusion, WFA + ‐M2BP might be a feasible predictive marker of fibrosis in HIV/HCV coinfected patients.
机译：目的：研究人类免疫缺陷病毒（HIV）和肝炎？C病毒（HCV）合并感染的患者，肝衰竭的进展据报道比HCV单一感染的患者更为严重。紫藤凝集素阳性的人Mac-2结合蛋白（WFA+-M2BP）是公认的肝纤维化糖类生物标志物，具有独特的纤维化相关糖类改变。我们分析了HIV/HCV联合感染患者的M2BP水平，作为预测肝纤维化的可能标志物。方法检测31例HIV/HCV联合感染患者的M2BP，分析WFA+-M2BP与几种纤维化、肝功能和肿瘤标志物的相关性。我们通过进行倾向评分匹配分析，比较了HIV/HCV联合感染患者和HCV单一感染患者的WFA+-M2BP水平。结果在HIV/HCV联合感染患者中，血清WFA+-M2BP水平与标记物类型密切相关？IV胶原蛋白、透明质酸和甲胎蛋白，但不是维生素K缺乏引起的蛋白质-II。在与HCV单感染患者相匹配的倾向评分中，HIV/HCV联合感染患者的WFA+-M2BP水平显著高于HCV单感染患者。结论总之，WFA+-M2BP可能是HIV/HCV联合感染患者纤维化的一个可行预测指标。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号