Oxyresveratrol suppresses lipopolysaccharide-induced inflammatory responses in murine macrophages

HS Lee; DH Kim; JE Hong; J-Y Lee; EJ Kim

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Oxyresveratrol suppresses lipopolysaccharide-induced inflammatory responses in murine macrophages

机译：oxyresveratrol抑制鼠巨噬细胞中的脂多糖诱导的炎症反应

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Excessive inflammation is considered a critical factor in many human diseases. Oxyresveratrol(trans-2,3′,4,5′-tetrahydroxystilbene), a natural hydroxystilbene, has been shown to possess antioxidant and free radical-scavenging activity. In this study, we investigated the effects of oxyresveratrol (OxyR) on the lipopolysaccharide (LPS)-induced production of inflammatory cytokines and mediators and further explored the mechanism of action in RAW264.7 murine macrophage cell line. Production of nitric oxide (NO), prostaglandin E2 (PGE2), messenger RNA (mRNA) and protein expressions of inducible nitric oxide

机译：过度炎症被认为是许多人类疾病的关键因素。羟基白藜芦醇（反式-2,3′，4,5′-四羟基二苯乙烯）是一种天然羟基二苯乙烯，具有抗氧化和清除自由基的活性。在本研究中，我们研究了氧化白藜芦醇（OxyR）对脂多糖（LPS）诱导的炎症细胞因子和介质产生的影响，并进一步探讨了RAW264的作用机制。7小鼠巨噬细胞系。一氧化氮（NO）、前列腺素E2（PGE2）、信使RNA（mRNA）和诱导型一氧化氮蛋白表达的产生

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《Human and Experimental Toxicology》 |2015年第8期|共11页
作者
HS Lee; DH Kim; JE Hong; J-Y Lee; EJ Kim;
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Department of Food Science and Nutrition Dongseo University Busan Republic of Korea;

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正文语种 eng
中图分类毒物学（毒理学）;
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2. Gene knockout or inhibition of macrophage migration inhibitory factor alleviates lipopolysaccharide-induced liver injury via inhibiting inflammatory response [J] . Yu-Lei Gu, Li-Li Xiao, De-Jian Li, 国际肝胆胰疾病杂志（英文版） . 2021,第005期
3. Tea Polyphenols Reducing Lipopolysaccharide-induced Inflammatory Responses in RAW264.7 Macrophages via NF-κB Pathway [J] . SU Siyi, FENG Shibin, LI Jinchun, 高等学校化学研究（英文版） . 2019,第006期
4. Oxyresveratrol suppresses lipopolysaccharide-induced inflammatory responses in murine macrophages [J] . HS Lee, DH Kim, JE Hong, Human and Experimental Toxicology . 2015,第8期

机译：oxyresveratrol抑制鼠巨噬细胞中的脂多糖诱导的炎症反应
5. Zinc L-carnosine suppresses inflammatory responses in lipopolysaccharide-induced RAW 264.7 murine macrophages cell line via activation of Nrf2/HO-1 signaling pathway [J] . Ooi Theng Choon, Chan Kok Meng, Sharif Razinah Immunopharmacology and immunotoxicology . 2017,第1a6期

机译：锌L-肉核苷酸通过NRF2 / HO-1信号通路的活化抑制脂多糖诱导的原料264.7鼠巨噬细胞系中的炎症反应
6. Pulchellamin G, an amino acid-sesquiterpene lactone, from Saussurea pulchella suppresses lipopolysaccharide-induced inflammatory responses via heme oxygenase-1 expression in murine peritoneal macrophages [J] . Lee Dong-Sung, Choi Hyun-Gyu, Woo Kyeong Wan, European Journal of Pharmacology: An International Journal . 2013,第1a3期

机译：来自Saussurea Pulchella的氨基酸 - 酪蛋白萜烯内酯的脉冲素G抑制了血红素氧合酶-1表达的脂多糖诱导的炎症反应在鼠腹膜巨噬细胞中
7. Hyperosmolar Potassium Depolarization Suppresses Pro-inflammatory Macrophage Activation [C] . Joshua Enrdt-Marino, Hongyu Chen, Mariah S. Hahn Society for Biomaterials annual meeting and exposition . 2019

机译：高渗钾离子去极化抑制促炎性巨噬细胞活化
8. Exposure to polybrominated diphenyl ethers (PBDEs) suppresses the release of pro-inflammatory products by alveolar macrophages in vitro. [D] . Hennigar, Stephen R. 2010

机译：暴露于多溴二苯醚（PBDEs）会抑制肺泡巨噬细胞在体外释放促炎性产物。
9. Cyclovirobuxinum D suppresses lipopolysaccharide-induced inflammatory responses in murine macrophages in vitro by blocking JAK-STAT signaling pathway [O] . Dan Guo, Jing-rong Li, Ying Wang, 2014

机译：Cyclovirobuxinum D通过阻断JAK-STAT信号通路抑制体外脂多糖诱导的小鼠巨噬细胞炎症反应
10. Cyclovirobuxinum D suppresses lipopolysaccharide-induced inflammatory responses in murine macrophages in vitro by blocking JAK-STAT signaling pathway [O] . Dan Guo, Jing-rong Li, Ying Wang, 2014

机译：Cyclovirobucum D通过阻塞Jak-Stat信号通路，抑制在体外尿床巨噬细胞中的脂多糖诱导的炎症反应
11. 1,25-Dihydroxyvitamin D3 Suppresses TLR8 Expression and TLR8-Mediated Inflammatory Responses in Monocytes In Vitro and Experimental Autoimmune Encephalomyelitis In Vivo. [R] . Li, B., Baylink, D. J., Deb, C., 2013

机译：1,25-二羟基维生素D3抑制体外单核细胞中的TLR8表达和TLR8介导的炎症反应以及体内实验性自身免疫性脑脊髓炎。

Oxyresveratrol suppresses lipopolysaccharide-induced inflammatory responses in murine macrophages

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