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首页> 外文期刊>Human and Experimental Toxicology >Hepatoprotective effect of Omega-3 PUFAs against acute paracetamol-induced hepatic injury confirmed by FTIR
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Hepatoprotective effect of Omega-3 PUFAs against acute paracetamol-induced hepatic injury confirmed by FTIR

机译：OMEGA-3 PUFA对急性扑热氨基酚诱导的肝损伤的肝脏保护作用

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摘要

Acute paracetamol over dose-induced hepatotoxicity is considered an important medical hazard especially among women. Omega-3 long-chain polyunsaturated fatty acids (Omega-3 PUFAs) daily doses are nowadays recommended for their antioxidant and anti-inflammatory potentials. Fourier transform infrared (FTIR) spectroscopy is considered a reliable method in analyzing cellular alterations and is now efficiently used to diagnose several diseases and the efficacy of drugs even in the early stages. The aim of our study was to evaluate the hepatoprotective effect of Omega-3 PUFAs against paracetamol-induced hepatotoxicity in rats confirmed through measuring protein alterations in hepatocytes by FTIR. Rats were pretreated with Omega-3 PUFAs (50 and 100 mg/kg) for 21 days prior to oral ingestion of paracetamol. FTIR results revealed that Omega-3 PUFAs (50 mg/kg) limited the toxic effects of paracetamol by restoring the hepatic amide I to amide II ratio. In addition; biochemical analyses demonstrated that serum ALT, AST, Cholesterol, LDL-cholesterol and Il-6 levels as well as hepatic TNF-α, MDA, NOx levels were decreased. Besides; serum HDL-cholesterol level and hepatic GSH level were increased. Histopathological examinations of hepatic sections validated the hepatoprotective potential. The overall effect of this dose was comparable to those of the usual recommended hepatoprotective supplement; silymarin. In conclusion; it would be recommended to use Omega-3 PUFAs in low doses on daily bases as a hepatoprotective agent.
机译：对乙酰氨基酚过量引起的急性肝毒性被认为是一种重要的医学危害，尤其是在女性中。目前推荐每日剂量的ω-3长链多不饱和脂肪酸（ω-3 PUFA）具有抗氧化和抗炎作用。傅里叶变换红外光谱（FTIR）被认为是分析细胞变化的可靠方法，现在被有效地用于诊断几种疾病和药物的疗效，甚至在早期阶段也是如此。我们的研究目的是评估Omega-3多不饱和脂肪酸对大鼠扑热息痛诱导的肝毒性的肝保护作用，通过FTIR测量肝细胞中的蛋白质变化来证实。大鼠在口服扑热息痛前用ω-3多不饱和脂肪酸（50和100 mg/kg）预处理21天。FTIR结果显示，ω-3多不饱和脂肪酸（50 mg/kg）通过恢复肝脏酰胺I与酰胺II的比例来限制对乙酰氨基酚的毒性作用。此外生化分析显示，血清ALT、AST、胆固醇、LDL胆固醇和Il-6水平以及肝脏TNF-α、MDA、NOx水平均降低。此外血清HDL胆固醇水平和肝脏GSH水平升高。肝脏切片的组织病理学检查证实了肝脏保护的潜力。该剂量的总体效果与通常推荐的保肝补充剂相当；水飞蓟素。总之；建议每天使用低剂量Omega-3多不饱和脂肪酸作为肝脏保护剂。

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