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首页> 外文期刊>Annals of Clinical and Laboratory Science: Official Journal of the Association of Clinical Scientists >Negative results of a rapid antibody test for HIV in a 16-month-old infant with AIDS.
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Negative results of a rapid antibody test for HIV in a 16-month-old infant with AIDS.

机译：对一个16个月大的AIDS婴儿进行HIV快速抗体检测的阴性结果。

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摘要

In a 16-mo-old infant born to an HIV-infected mother, repeatedly negative results of a HIV rapid antibody test had been reported during the past 6 mo. The infant presented with several HIV-defining illnesses and HIV RT-PCR testing confirmed the presence of HIV infection. There are at least 2 possible explanations for the child's false-negative rapid HIV test results: First, his primary antibody production may have been suppressed by the presence of maternal IgG antibodies. Second, his mother was highly immunosuppressed, so that the low level of maternally derived IgG was only detected by HIV-EIA and Western blot. Our data suggest that the HIV rapid antibody test may not be sufficiently sensitive to detect HIV antibodies in infants aged <18 mo.
机译：在一个被HIV感染的母亲所生的16个月大婴儿中，过去6个月中曾多次报告HIV快速抗体检测阴性。这名婴儿出现了几种定义HIV的疾病，并且HIV RT-PCR测试证实存在HIV感染。至少有2种可能的解释说明该儿童的HIV快速检测结果为假阴性：首先，母体IgG抗体的存在可能抑制了他的一抗的产生。其次，他的母亲被高度免疫抑制，因此仅通过HIV-EIA和Western blot检测到母体来源的IgG水平较低。我们的数据表明，对于18岁以下的婴儿，HIV快速抗体检测可能不足以检测HIV抗体。

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