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首页> 外文期刊>Annals of oncology: official journal of the European Society for Medical Oncology >Standard treatment of female patients with breast cancer decreases substantially for women aged 70 years and older: a German clinical cohort study.
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Standard treatment of female patients with breast cancer decreases substantially for women aged 70 years and older: a German clinical cohort study.

机译：一项德国临床队列研究显示，对于70岁以上的女性，女性乳腺癌患者的标准治疗方法大大降低。

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BACKGROUND: Standard treatment of patients with breast cancer decreases with age and older persons are mostly excluded from clinical trials. We hypothesized that non-adherence to treatment guidelines occurs for women aged > or =70 years and changes overall survival (OAS) and disease-free survival (DFS). PATIENTS AND METHODS: We enrolled 1922 women aged > or =50 years with histologically confirmed invasive breast cancer treated at the University of Ulm from 1992 to 2005. Adherence to guidelines and effects on OAS and DFS for women aged > or =70 years was compared with that for younger women (50-69 years). RESULTS: Women >70 years less often received recommended breast-conserving therapy (70-79 years: 74%-83%; >79 years: 54%) than women aged < or =69 years (93%). Non-adherence to the guidelines on radiotherapy (<70 years: 9%; 70-79 years: 14%-27%; >79 years: 60%) and chemotherapy (<70 years: 33%; 70-79 years: 54%-77%; > 79 years: 98%) increased with age. Omission of radiotherapy significantly decreased OAS [< or =69 years: hazard ratio (HR) = 3.29; P <0.0001; > or =70 years: HR = 1.89; P = 0.0005] and DFS (< or =69 years: HR = 3.45; P <0.0001; > or =70 years: HR = 2.14; P <0.0001). OAS and DFS did not differ significantly for adherence to surgery, chemotherapy, or endocrine therapy. CONCLUSION: Our study confirms that substandard treatment increases considerably with age. Omission of radiotherapy had the greatest impact on OAS and DFS in the elderly population.
机译：背景：乳腺癌患者的标准治疗会随着年龄的增长而降低，老年人大多被排除在临床试验之外。我们假设年龄大于或等于70岁的女性发生了不遵守治疗指南的情况，并改变了总生存期（OAS）和无病生存期（DFS）。患者与方法：我们从1992年至2005年在乌尔姆大学（University of Ulm）招募了1922名年龄≥50岁且经组织学证实为浸润性乳腺癌的女性。比较了年龄≥70岁的女性对OAS和DFS的指导方针和影响与年轻女性（50-69岁）相对应。结果：> 70岁以下的女性比推荐年龄<或= 69岁的女性少接受推荐的保乳疗法（70-79岁：74％-83％;> 79岁：54％）。不遵守放疗指南（<70岁：9％; 70-79岁：14％-27％;> 79岁：60％）和化学疗法（<70岁：33％; 70-79岁：54 ％-77％;> 79岁：98％）。省略放疗可显着降低OAS [<或= 69岁：危险比（HR）= 3.29; P <0.0001; >或= 70年：HR = 1.89; P = 0.0005]和DFS（<或= 69年：HR = 3.45; P <0.0001;>或= 70年：HR = 2.14; P <0.0001）。 OAS和DFS在坚持手术，化学疗法或内分泌疗法方面无显着差异。结论：我们的研究证实，不合标准的治疗随着年龄的增长而大大增加。放射治疗的遗漏对老年人的OAS和DFS影响最大。

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