...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Animal Cells and Systems >Protective effect of Phellodendri Cortex against lipopolysaccharide-induced memory impairment in rats.
【24h】

Protective effect of Phellodendri Cortex against lipopolysaccharide-induced memory impairment in rats.

机译：黄柏皮层对脂多糖诱导的大鼠记忆损伤的保护作用。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The purpose of this study was to examine whether Phellodendri Cortex extract (PCE) could improve learning and memory impairments caused by lipopolysaccharide (LPS)-induced inflammation in the rat brain. The effect of PCE on modulating pro-inflammatory mediators in the hippocampus and its underlying mechanism were investigated. Injection of LPS into the lateral ventricle caused acute regional inflammation and subsequent deficits in spatial learning ability in the rats. Daily administration of PCE (50, 100, and 200 mg/kg, i.p.) for 21 days markedly improved the LPS-induced learning and memory disabilities in the Morris water maze and passive avoidance test. PCE administration significantly decreased the expression of pro-inflammatory mediators such as tumor necrosis factor- alpha , interleukin-1 beta , and cyclooxygenase-2 mRNA in the hippocampus, as assessed by RT-PCR analysis and immunohistochemistry. Together, these findings suggest that PCE significantly attenuated LPS-induced spatial cognitive impairment through inhibiting the expression of pro-inflammatory mediators in the rat brain. These results suggested that PCE may be effective in preventing or slowing the development of neurological disorders, including Alzheimer's disease, by improving cognitive and memory function because of its anti-inflammation activity in the brain.
机译：这项研究的目的是检查黄柏提取物（PCE）是否可以改善由脂多糖（LPS）诱导的大鼠大脑炎症引起的学习和记忆障碍。研究了PCE对调节海马促炎性介质的作用及其潜在机制。向侧脑室注射LPS会引起大鼠急性局部发炎和随后的空间学习能力下降。在莫里斯水迷宫和被动回避测试中，每天施用PCE（50、100和200 mg / kg，腹腔注射）持续21天，可显着改善LPS诱导的学习和记忆障碍。通过RT-PCR分析和免疫组织化学评估，PCE给药显着降低了海马中促炎性介质的表达，例如肿瘤坏死因子-α，白介素-1β和环氧合酶-2 mRNA。在一起，这些发现表明PCE通过抑制大鼠脑中促炎性介质的表达，大大减轻了LPS诱导的空间认知障碍。这些结果表明，由于PCE具有抗炎作用，因此它可以通过改善认知和记忆功能，有效预防或减缓包括阿尔茨海默氏病在内的神经系统疾病的发展。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号