Synthesis and structure of a new trinuclear nickel(II) complex bridged by N-[3-(Dimethylamino)propyl]-N '-(2-hydroxyphenyl)oxamido: in vitro anticancer activities, and reactivities toward DNA and protein

Wang Ju-Ju; Wang Ling-Yang; Zheng Kang; Li Yan-Tuan; Yan Cui-Wei; Wu Zhi-Yong

首页> 外文期刊>Journal of biochemical and molecular toxicology >Synthesis and structure of a new trinuclear nickel(II) complex bridged by N-[3-(Dimethylamino)propyl]-N '-(2-hydroxyphenyl)oxamido: in vitro anticancer activities, and reactivities toward DNA and protein

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Synthesis and structure of a new trinuclear nickel(II) complex bridged by N-[3-(Dimethylamino)propyl]-N '-(2-hydroxyphenyl)oxamido: in vitro anticancer activities, and reactivities toward DNA and protein

机译：通过N-[3-（二甲基氨基）丙基桥面的新三核镍（II）复合物的合成及结构 - N-（2-羟基苯基）羟肟酰胺：体外抗癌活性，以及DNA和蛋白的反应性

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A new trinickel(II) complex bridged by N-[3-(dimethylamino)propyl]-N'-(2-hydroxylphenyl)oxamido (H(3)pdmapo), namely [Ni-3(pdmapo)(2)(H2O)(2)]4CH(3)OH, was synthesized and characterized by X-ray single-crystal diffraction and other methods. In the molecule, two symmetric cispdmapo3- mononickel(II) complexes as a " complex ligand" using the carbonyl oxygen atoms coordinate to the center nickel(II) ion situated on an inversion point. The NiNi distance through the oxamido bridge is 5.2624(4) angstrom. The center nickel(II) ion and the lateral ones have octahedral and square-planar coordination geometries, respectively. In the crystal, a three-dimensional supramolecular network dominated by hydrogen bonds is observed. The reactivity toward DNA/ protein bovine serum albumin (BSA) revealed that the complex could interact with herring sperm DNA (HS-DNA) through the intercalation mode and quench the intrinsic fluorescence of BSA via a staticmechanism. The in vitro anticancer activities suggested that the complex is active against the selected tumor cell lines.

机译：合成了一种由N-[3-（二甲氨基）丙基]-N'-（2-羟基苯基）草酰胺基（H（3）pdmapo）桥联的新型三硝基（II）配合物[Ni-3（pdmapo）（2）（H2O）（2）]4CH（3）OH，并用X射线单晶衍射等方法对其进行了表征。在该分子中，两个对称的顺式PdMAPO3-单镍（II）配合物作为“复合配体”，使用羰基氧原子与位于反转点上的中心镍（II）离子配位。通过恶酰胺桥的尼尼距离为5.2624（4）埃。中心镍（II）离子和侧向镍（II）离子分别具有八面体和正方形平面配位几何形状。在晶体中，观察到了以氢键为主的三维超分子网络。对DNA/蛋白质牛血清白蛋白（BSA）的反应性表明，该复合物可以通过插层方式与鲱鱼精子DNA（HS-DNA）相互作用，并通过静态机制猝灭BSA的固有荧光。体外抗癌活性表明，该复合物对选定的肿瘤细胞系具有活性。

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来源
《Journal of biochemical and molecular toxicology》 |2017年第1期|共11页
作者
Wang Ju-Ju; Wang Ling-Yang; Zheng Kang; Li Yan-Tuan; Yan Cui-Wei; Wu Zhi-Yong;
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作者单位

Ocean Univ China Sch Med &

Pharm Qingdao 266003 Peoples R China;

Ocean Univ China Sch Med &

Pharm Qingdao 266003 Peoples R China;

Ocean Univ China Sch Med &

Pharm Qingdao 266003 Peoples R China;

Ocean Univ China Sch Med &

Pharm Qingdao 266003 Peoples R China;

Ocean Univ China Coll Marine Life Sci Qingdao 266003 Peoples R China;

Ocean Univ China Sch Med &

Pharm Qingdao 266003 Peoples R China;

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原文格式 PDF
正文语种 eng
中图分类生物化学;
关键词
Crystal Structure; Trinickel(II) Complex; Cytotoxicity; DNA/Protein Binding;

机译：晶体结构;Trinickel（II）复合物;细胞毒性;DNA /蛋白质结合;

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Synthesis and structure of a new trinuclear nickel(II) complex bridged by N-[3-(Dimethylamino)propyl]-N '-(2-hydroxyphenyl)oxamido: in vitro anticancer activities, and reactivities toward DNA and protein

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