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首页> 外文期刊>Journal of biochemical and molecular toxicology >Assessment of chromosomal aberrations among agricultural workers exposed to pesticides in Punjab, India
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Assessment of chromosomal aberrations among agricultural workers exposed to pesticides in Punjab, India

机译：在印度旁遮普邦暴露于杀虫剂的农业工人染色体畸变的评估

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摘要

Chromosomal aberrations (CAs) are an important tool for assessment of exposure to pesticides. Genotoxic potential of pesticides is a principal risk factor for long-term health effects. The present study was aimed toward the assessment of CAs among agricultural workers exposed to pesticides and comparison with nonagricultural workers not exposed to pesticides. A total of 296 subjects were enrolled in the study: exposed (n = 148) and nonexposed subjects (n = 148) from Punjab. A significantly high frequency of aberrations was seen in peripheral blood lymphocytes of exposed subjects as compared with nonexposed ones. Most CAs were present as loss (aneuploidy) and were observed significantly in subjects having a history of alcohol consumption. It can be, thus, concluded that agricultural workers exposed to a mixture of pesticides, in addition to being alcoholic, are at a greater risk of genotoxic damage. It is highly recommended that the agricultural workers are educated regarding the potential hazards of occupational exposure to pesticides.
机译：染色体畸变（CAs）是评估农药暴露的重要工具。农药的潜在基因毒性是长期健康影响的主要风险因素。本研究旨在评估接触农药的农业工人中的CAs，并与未接触农药的非农业工人进行比较。共有296名受试者参加了这项研究：来自旁遮普的暴露受试者（n=148）和未暴露受试者（n=148）。与未暴露的受试者相比，暴露受试者的外周血淋巴细胞出现显著高频率的畸变。大多数CAs以丢失（非整倍体）的形式出现，并且在有饮酒史的受试者中显著观察到。因此，可以得出结论，接触混合杀虫剂的农业工人除了酗酒之外，还有更大的基因毒性损害风险。强烈建议对农业工人进行农药职业接触潜在危害的教育。

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