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首页> 美国政府科技报告 >Cytogenetic Study of Workers Exposed to Ethylene Oxide: Analysis of the Chromosomal Aberration Data and Overall Conclusions from the Analyses of Sister Chromatid Exchanges and Chromosomal Aberrations
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Cytogenetic Study of Workers Exposed to Ethylene Oxide: Analysis of the Chromosomal Aberration Data and Overall Conclusions from the Analyses of Sister Chromatid Exchanges and Chromosomal Aberrations

机译：接触环氧乙烷的工人的细胞遗传学研究：染色体畸变数据的分析和姐妹染色单体交换和染色体畸变分析的总体结论

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A survey of sister chromatid exchange (SCE) incidence among workers occupationally exposed to ethylene-oxide was conducted. The effects of smoking were also investigated. The cohort consisted of 44 workers in ethylene-oxide production units and 27 workers in a quality assurance laboratory having exposure to ethylene-oxide and other chemicals. Circulating lymphocytes were obtained from the subjects and assayed for SCEs. Personal ethylene-oxide exposures were measured. Median exposures to ethylene-oxide were 0.19 to 1.0 part per million (ppm) in the production workers and 0.14 to 10.9 ppm in the laboratory workers. Cigarette smoking comparisons had a higher statistically significant incidence of SCEs than nonsmokers. Nonsmoking production workers had a marginally statistically significant elevation of SCEs compared to smoking comparisons. Cigarette smoking production workers had an insignificant excess incidence of SCEs. SCE incidence was statistically significantly increased in smoking and nonsmoking laboratory workers. The data suggests an additive relationship between the effect of cigarette smoking and employment in ethylene-oxide production units. The effects of smoking and employment in the laboratory are less than additive.

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