Mitochondriotropic action and DNA protection: Interactions between phenolic acids and enzymes

Tatiane Silva de Abreu; Mariana Aparecida Braga; Anderson Assaid Simao; Marcus Vinicius Cardoso Trento; Mateus Willian de Faria Eleuterio; Luciana Lopes Silva Pereira; Elaine Fontes Ferreira da Cunha; Silvana Marcussi

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Mitochondriotropic action and DNA protection: Interactions between phenolic acids and enzymes

机译：线粒体激动作用和DNA保护：酚酸和酶之间的相互作用

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The protective action of caffeic (CA) and syringic (SA) acids on the genotoxicity exercised by snake venoms was investigated in this study. Molecular interactions between phenolic acids and the enzyme succinate dehydrogenase were also explored. In the electrophoresis assay, SA did not inhibit the genotoxicity induced by the venom. However, CA partially inhibited DNA degradation. In the comet assay, SA and CA exerted an inhibitory effect on the venom-induced fragmentation. Succinate dehydrogenase presented, in computational analyzes, favorable energies to the molecular bond to both the malonic acid and the phenolic compounds evaluated. In the enzymatic activity assays, SA inhibited succinate dehydrogenase and interfered in the interaction of malonic acid. Meanwhile, CA potentiated the inhibition exerted by the malonic acid. The results suggest transient interactions between toxins present in venoms and phenolic acids, mainly by hydrogen interactions, which corroborate with the data from previous works.

机译：研究了咖啡酸（CA）和丁香酸（SA）对蛇毒遗传毒性的保护作用。还探讨了酚酸和琥珀酸脱氢酶之间的分子相互作用。在电泳分析中，SA不抑制毒液诱导的遗传毒性。然而，CA部分抑制了DNA降解。在彗星试验中，SA和CA对毒液诱导的裂解产生抑制作用。在计算分析中，琥珀酸脱氢酶为丙二酸和酚类化合物的分子键提供了有利的能量。在酶活性测定中，SA抑制琥珀酸脱氢酶并干扰丙二酸的相互作用。同时，CA增强了丙二酸的抑制作用。结果表明，毒液中存在的毒素和酚酸之间存在短暂的相互作用，主要是通过氢相互作用，这与先前工作的数据相一致。

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来源
《Journal of biochemical and molecular toxicology》 |2020年第1期|共1页
作者
Tatiane Silva de Abreu; Mariana Aparecida Braga; Anderson Assaid Simao; Marcus Vinicius Cardoso Trento; Mateus Willian de Faria Eleuterio; Luciana Lopes Silva Pereira; Elaine Fontes Ferreira da Cunha; Silvana Marcussi;
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Department of Chemistry Biochemistry Laboratory Universidade Federal de Lavras (UFLA) Campus;

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正文语种 eng
中图分类生物化学;
关键词
comet assay; enzymatic inhibitor; genotoxicity; phenolic compounds; snake venom; succinate dehydrogenase;

机译：彗星测定;酶促抑制剂;遗传毒性;酚类化合物;蛇毒液;琥珀酸钠脱氢酶;

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4. Lead Induced Disorders in Hematopoietic and Drug Metabolizing Enzyme System and Their Protection by Ascorbic Acid Supplementation [J] . 生物医学与环境科学（英文版） . 1998,第001期
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6. Virgin Olive Oil Enriched with Its Own Phenols or Complemented with Thyme Phenols Improves DNA Protection against Oxidation and Antioxidant Enzyme Activity in Hyperlipidemic Subjects [J] . Romeu Marta, Rubio Laura, Sanchez-Martos Vanessa, Journal of Agricultural and Food Chemistry . 2016,第9期

机译：富含其自身酚或百里香酚的初榨橄榄油可改善高脂血症患者抗氧化和抗氧化酶活性的DNA保护作用
7. Virgin Olive Oil Enriched with Its Own Phenolics or Complemented with Thyme Phenols Improves DNA Protection against Oxidation and Antioxidant Enzyme Activity in Hyperlipidemic Subjects (vol 64, pg 1879, 2016) [J] . Romeu Marta, Rubio Laura, Sanchez-Martos Vanessa, Journal of Agricultural and Food Chemistry . 2016,第24期

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8. Inhibitory Action of Phenolic Compounds on Cell Wall Degrading Enzymes : Host Pathogen Interaction in Fusarium Wilt of Cumin [J] . M K MANDAVIA, H P GAJERA, N A KHAN, Indian Journal of Agricultural Biochemistry . 2003,第1期

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机译：历史和现代硬红春小麦的比较：近邻，酶活性，酚酸和淀粉特性的分析。
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13. Nucleic acid enzymes for cleaving DNA [R] . 2001

机译：用于切割DNa的核酸酶

Mitochondriotropic action and DNA protection: Interactions between phenolic acids and enzymes

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