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首页> 外文期刊>Journal of biochemical and molecular toxicology >Effect of citronellol on NF-kB inflammatory signaling molecules in chemical carcinogen-induced mammary cancer in the rat model
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Effect of citronellol on NF-kB inflammatory signaling molecules in chemical carcinogen-induced mammary cancer in the rat model

机译：CITRONELLOL对大鼠模型中化学致癌乳腺癌NF-KB炎症信号分子的影响

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摘要

Inflammation plays a vital role in the process of carcinogenesis and anti-inflammatory properties of phytochemicals are gaining more attention in the chemoprevention of cancer. The present study was designed to evaluate the anti-inflammatory potential of citronellol (CT) on 7,12-dimethylbenz(α)anthracene (DMBA)-induced mammary carcinogenesis in rats. The inflammation-associated gene and protein markers were analyzed by immunohistochemistry, reverse transcription polymerase chain reaction, and Western blot techniques. Markers such as nuclear factor-κB (NF-κB), tumor necrosis factor-α, interleukin-6 (IL-6), cyclooxygenase-2, macrophage inflammatory protein-1α, and inducible nitric oxide synthase are upregulated in DMBA-alone-treated mammary tumor tissues. The oral administration of CT (50mg/kg BW) to DMBA-treated rats signific6antly downregulated the expression NF-kB and other inflammatory markers, and also increased the level of IL-10 in mammary tissues. The results suggested that the anti-inflammatory potential of CT prevented the incidence of chemical carcinogen-induced mammary cancer in rats.
机译：炎症在致癌过程中起着至关重要的作用，植物化学物质的抗炎特性在癌症的化学预防中越来越受到重视。本研究旨在评估香茅醇（CT）对7,12-二甲基苯并（α）蒽（DMBA）诱导的大鼠乳腺癌发生的抗炎作用。通过免疫组织化学、逆转录聚合酶链反应和免疫印迹技术分析炎症相关基因和蛋白质标记。核因子-κB（NF-κB）、肿瘤坏死因子-α、白细胞介素-6（IL-6）、环氧合酶-2、巨噬细胞炎性蛋白-1α和诱导型一氧化氮合酶等标记物在DMBA单独治疗的乳腺肿瘤组织中上调。给DMBA治疗的大鼠口服CT（50mg/kg BW）可显著下调NF-kB和其他炎症标记物的表达，并增加乳腺组织中IL-10的水平。结果表明，CT的抗炎潜能可以预防化学致癌物诱发的大鼠乳腺癌的发生。

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