Deoxyshikonin inhibits cisplatin resistance of non-small-cell lung cancer cells by repressing Akt-mediated ABCB1 expression and function

Suhong Zhang; Yi Wang

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Deoxyshikonin inhibits cisplatin resistance of non-small-cell lung cancer cells by repressing Akt-mediated ABCB1 expression and function

机译：通过抑制AKT介导的ABB1表达和功能，脱氧性酮抑制非小细胞肺癌细胞的顺铂抗性

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Drug resistance is a large challenge for the treatment of non-small-cell lung cancer (NSCLC). Deoxyshikonin is the naphthoquinol compound with anticancer activity. However, the role and mechanism of deoxyshikonin in cisplatin resistance of NSCLC remain poorly understood. Cell viability was assessed using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-tetrazolium bromide assay. Cell apoptosis was evaluated by flow cytometry and caspase-3 activity. We found that cisplatin-resistant A549/cis and H1299/cis cells had higher cisplatin resistance than A549 and H1299 cells, respectively. Deoxyshikonin contributed to cisplatin-induced viability inhibition and apoptosis in A549/cis and H1299/cis cells. Moreover, deoxyshikonin inhibited phos-phorylation of Akt and the expression and function of ATP-binding cassette subfamily B member 1 (ABCB1). Activation of protein kinase B (Akt) pathway attenuated the effect of deoxyshikonin on cisplatin resistance and ABCB1 expression and function in A549/cis and H1299/cis cells. In conclusion, deoxyshikonin suppressed cisplatin resistance in cisplatin-resistant NSCLC cells by repressing Akt signaling-mediated ABCB1 expression.

机译：耐药性是非小细胞肺癌（NSCLC）治疗面临的一大挑战。脱氧硫Konin是一种具有抗癌活性的萘醌化合物。然而，脱氧硫Konin在NSCLC顺铂耐药中的作用和机制尚不清楚。使用3-（4,5-二甲基噻唑-2-基）-2,5-二苯基四唑溴化法评估细胞活力。流式细胞术和caspase-3活性检测细胞凋亡。我们发现，对顺铂耐药的A549/cis和H1299/cis细胞对顺铂的耐药性分别高于A549和H1299细胞。脱氧硫Konin有助于顺铂诱导的A549/cis和H1299/cis细胞活性抑制和凋亡。此外，脱氧硫Konin抑制Akt的磷酸化以及ATP结合盒亚家族B成员1（ABCB1）的表达和功能。蛋白激酶B（Akt）途径的激活减弱了脱氧硫Konin对A549/cis和H1299/cis细胞顺铂耐药性和ABCB1表达及功能的影响。总之，脱氧硫Konin通过抑制Akt信号介导的ABCB1表达，抑制顺铂耐药NSCLC细胞的顺铂耐药。

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《Journal of biochemical and molecular toxicology》 |2020年第10期|共1页
作者
Suhong Zhang; Yi Wang;
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作者单位

Department of Respiratory and Critical Care Medicine Huaihe Hospital of Henan University Kaifeng;

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正文语种 eng
中图分类生物化学;
关键词
ABCB1; Akt; cisplatin resistance; deoxyshikonin; non-small-cell lung cancer;

机译：ABCB1;AKT;顺铂抗性;脱氧性酮;非小细胞肺癌;

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Deoxyshikonin inhibits cisplatin resistance of non-small-cell lung cancer cells by repressing Akt-mediated ABCB1 expression and function

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