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首页> 外文期刊>Journal of biochemical and molecular toxicology >Cinnamaldehyde and hesperetin attenuate TNBS-induced ulcerative colitis in rats through modulation of the JAk2/STAT3/SOCS3 pathway
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Cinnamaldehyde and hesperetin attenuate TNBS-induced ulcerative colitis in rats through modulation of the JAk2/STAT3/SOCS3 pathway

机译：Cinnamaldehyde和Hesperetin通过调制JAK2 / Stat3 / SoCS3路径来衰减大鼠的TNBS诱导的溃疡性结肠炎

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Ulcerative colitis is an autoimmune inflammatory disorder with a negative impact on the life quality of patients. Cinnamaldehyde and hesperetin were chosen due to their antioxidants and anti-inflammatory effects. This study explored the protective effects of cinnamaldehyde (40 and 90 mg/kg, po) and hesperetin (50 and 100 mg/kg, po) on 2,4,6-trinitrobenzene sulfonic acid (TNBS)-induced ulcerative colitis in rats. Cinnamaldehyde and hesperetin significantly improved macroscopic and histo-pathological examinations with a significant reduction in myeloperoxidase and intracellular adhesion molecule-1 expression. They significantly reduced colon oxi-dative stress by a significant elevation in both reduced glutathione content and superoxide dismutase activity with a significant reduction of NO content. Furthermore, cinnamaldehyde and hesperetin alleviated the inflammatory injury by a significant reduction in interleukin-6 along with suppression of nuclear factor-κB, receptor for advanced glycation end products, and tumor necrosis factor-α expression. Moreover, cinnamaldehyde and hesperetin significantly decreased p-JAK2 and p-STAT3 while significantly increased suppressors of cytokine signaling 3 (SOCS3) protein expression. In conclusion, cinnamaldehyde and hesperetin counteracted TNBS-induced ulcerative colitis through antioxidant, anti-inflammatory properties as well as modulation of the JAk2/STAT3/SOCS3 pathway.
机译：溃疡性结肠炎是一种自身免疫性炎症性疾病，对患者的生活质量有负面影响。选择肉桂醛和橙皮素是因为它们具有抗氧化和抗炎作用。本研究探讨肉桂醛（40和90 mg/kg，po）和橙皮素（50和100 mg/kg，po）对2,4,6-三硝基苯磺酸（TNBS）诱导的大鼠溃疡性结肠炎的保护作用。肉桂醛和橙皮素显著改善宏观和组织病理检查，显著降低髓过氧化物酶和细胞内粘附分子-1的表达。他们通过显著提高还原型谷胱甘肽含量和超氧化物歧化酶活性，显著降低NO含量，从而显著降低结肠氧化应激。此外，肉桂醛和橙皮素通过显著降低白细胞介素-6以及抑制核因子-κB、晚期糖基化终产物受体和肿瘤坏死因子-α的表达来减轻炎症损伤。此外，肉桂醛和橙皮素显著降低p-JAK2和p-STAT3，同时显著增加细胞因子信号3（SOCS3）蛋白表达的抑制因子。总之，肉桂醛和橙皮素通过抗氧化、抗炎特性以及JAk2/STAT3/SOCS3通路的调节对抗TNBS诱导的溃疡性结肠炎。

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