Advanced glycation end products and their adverse effects: The role of autophagy

C. R. Sruthi; K. G. Raghu

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Advanced glycation end products and their adverse effects: The role of autophagy

机译：先进的糖化末端产品及其不利影响：自噬的作用

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The critical roles played by advanced glycation endproducts (AGEs) accumulation in diabetes and diabetic complications have gained intense recognition. AGEs interfere with the normal functioning of almost every organ with multiple actions like apoptosis, inflammation, protein dysfunction, mitochondrial dysfunction, and oxi-dative stress. However, the development of a potential treatment strategy is yet to be established. Autophagy is an evolutionarily conserved cellular process that maintains cellular homeostasis with the degradation and recycling systems. AGEs can activate autophagy signaling, which could be targeted as a therapeutic strategy against AGEs induced problems. In this review, we have provided an overview of the adverse effects of AGEs, and we put forth the notion that autophagy could be a promising targetable strategy against AGEs.

机译：晚期糖基化终产物（AGEs）积累在糖尿病和糖尿病并发症中的关键作用已得到广泛认可。AGEs通过凋亡、炎症、蛋白质功能障碍、线粒体功能障碍和缺氧应激等多种作用干扰几乎每个器官的正常功能。然而，潜在治疗策略的开发尚未确定。自噬是一种进化上保守的细胞过程，通过降解和循环系统维持细胞内稳态。AGEs可以激活自噬信号，这可能是针对AGEs诱导的问题的一种治疗策略。在这篇综述中，我们概述了AGEs的不良影响，并提出自噬可能是一种有希望的针对AGEs的策略。

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来源
《Journal of biochemical and molecular toxicology》 |2021年第4期|共1页
作者
C. R. Sruthi; K. G. Raghu;
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作者单位

Biochemistry and Molecular Mechanism Laboratory Agro-processing and Technology Division CSIR;

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原文格式 PDF
正文语种 eng
中图分类生物化学;
关键词
advanced glycation end products (AGEs); AGEs-RAGE axis; autophagy; diabetic complications; RAGE;

机译：先进的糖化末端产品（年龄）;年龄愤怒轴;自噬;糖尿病并发症;愤怒;

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2. The role of advanced glycation end products and their mechanism in DN [J] . 李奕茜, 王洋, 方朝晖, 世界中西医结合杂志（英文） . 2017,第003期
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4. The role of advanced glycation end products and their mechanism in DN [J] . 李奕茜1, 王洋2, 方朝晖3, 世界中西医结合杂志（英文） . 2017,第3)期
5. Autophagy Plays a Protective Role in Advanced Glycation End Product-Induced Apoptosis in Cardiomyocytes [J] . Pengfei Hu, Hui Zhou, Ming Lu, Cellular Physiology and Biochemistry . 2015,第2期

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6. The multifunctional roles of flavonoids against the formation of advanced glycation end products (AGEs) and AGEs-induced harmful effects [J] . Zhou Qian, Cheng Ka-Wing, Xiao Jianbo, Trends in Food Science & Technology . 2020,第1期

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7. Diverging effects of diabetes mellitus in patients with peripheral artery disease and abdominal aortic aneurysm and the role of advanced glycation end-products: ARTERY study ?￠?? protocol for a multicentre cross-sectional study [J] . J Boersema, J D Lefrandt, J C Breek, BMJ Open . 2017,第4期

机译：糖尿病在外周动脉疾病和腹主动脉瘤患者中的散发效应和晚期糖基化终产物的作用：动脉研究多中心横断面研究方案
8. The Role of Advanced Glycation End Products in Asthma and Chronic Obstructive Pulmonary Disease [C] . SJ. Wilson, C. Lai, C. Williams, Collegium Internationale Allergologicum . 2007

机译：晚期糖化末端产物在哮喘和慢性阻塞性肺病中的作用
9. Influence of Four Differently Processed Diets on Plasma Levels of Advanced Glycation End Products (Ages), Serum Levels of Receptor for Advanced Glycation End Products (Rage), Serum and Urine Metabolome, and Fecal Microbiome in Healthy Dogs [D] . ?Bridglalsingh, Siobhan 2020

机译：四种不同加工饮食对晚期糖糖末端产物（年龄），晚期糖糖末端产物（RAGE），血清和尿液代谢的血清受体水平的影响，以及健康犬的粪便微生物组
10. The role of autophagy in advanced glycation end product-induced proliferation and migration in rat vascular smooth muscle cells [O] . Zhigang Liu, Shuwei Huang, Pengfei Hu, 2018

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11. Autophagy Plays a Protective Role in Advanced Glycation End Product-Induced Apoptosis in Cardiomyocytes [O] . Pengfei Hu, Hui Zhou, Ming Lu, 2015

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12. Receptor for Advanced Glycation End Products (RAGE) as a Novel Target for Inhibiting Breast Cancer Bone Metastasis. [R] . Ganju, R. K. 2013

机译：晚期糖基化终产物受体（RaGE）作为抑制乳腺癌骨转移的新靶点。

Advanced glycation end products and their adverse effects: The role of autophagy

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